ArticleTransfusion2025
Preparation of cold-stored platelets on-demand: A novel approach to inventory management.
Article in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Preparation of cold-stored platelets on-demand: A novel approach to inventory management.Transfusion · 2025Article
- Cold-stored platelets: revisiting assumptions and addressing variability to support implementation.Frontiers in medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCold-stored platelets (CSP) are now being used to treat acute bleeding. However, as CSP are less suitable for prophylaxis, both room temperature (RT) platelets and CSP will be required, which complicates inventory management. The production of CSP "on-demand" from RT platelets may be a desirable option. This study investigated whether CSP could be prepared rapidly by cooling RT platelets in a fridge or freezer. STUDY DESIGN AND
methodsDouble apheresis platelet components (40% plasma/60% PAS-E) were sampled on Day 1 (RT baseline), then split into matched pairs (n = 10). One component was allocated to cold (2-6°C) storage and sampled at 2 h and 14 days. The other component was placed in a freezer (-30°C) and sampled every 5 min for 20 min (on-demand), then transferred to the fridge and sampled at 14 days.
resultsStorage in the fridge for 2 h reduced the temperature to 4.1 ± 0.7°C and induced loss of swirl, shape change, enhanced aggregation, and reduced clotting time. Changes to surface glycoproteins (CD61, CD42b, GPVI) and activation markers (phosphatidylserine, P-selectin, release of alpha-granule proteins, and extracellular vesicles) were not observed after 2 h but became evident after 14 days. Storage in the freezer for at least 15 min induced the expected "cold storage lesion" changes. DISCUSSION: The morphological and functional characteristics of CSP can be induced within 15 min by exposure to a standard blood-bank freezer, or 2 h in the fridge. This approach to prepare CSP "on-demand" may represent a viable option for balancing patient-tailored transfusion and inventory management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.