ArticleHuman vaccines & immunotherapeutics2025
Correlation between the immune response to COVID-19 vaccines and the constitutions of traditional Chinese medicine.
Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional Chinese Medicine (TCM) classifies individuals into constitution types that may influence physiological responses. SARS-CoV-2 vaccines induce spike-specific antibodies and activate B and T cells, including memory subsets. This study investigates whether TCM constitution types are associated with immune responses and adverse events following COVID-19 vaccination. From March 2021 to December 2023, 78 adults received two doses of the COVID-19 vaccine, including AstraZeneca, Moderna, MVC-COV1901, and Pfizer-BioNTech. PBMCs were collected before and after vaccination. Immune parameters-cytokines, antibody titers, dendritic cells (DCs), T cells, B cells, and memory T cell subsets-were measured. TCM constitution scores were determined using the Constitution in Chinese Medicine Questionnaire (CCMQ) before vaccination. Adverse reactions were recorded through structured surveys, and correlations between constitution scores and adverse events were analyzed using the Pearson correlation. Pre-vaccination TNF-α was negatively correlated with the gentleness constitution and positively with the qi-deficiency. DCs increased post-vaccination in individuals with qi-deficiency, phlegm-dampness, qi-depression, yin-deficiency, dampness-heat, and special diathesis constitutions. T cell proportions increased in yin-deficiency, dampness-heat, and special diathesis groups. Dampness-heat scores were negatively correlated with central memory T cell (Tcm) induction. No significant correlations were found between constitution types and antibody levels or neutralization. Adverse reactions were more frequent in individuals with phlegm-dampness, qi-depression, and blood-stasis constitutions, and less frequent in those with a gentleness constitution. TCM constitutions correlate with cellular immune responses and adverse reaction profiles, but not antibody production, after COVID-19 vaccination. This supports integrating TCM constitution frameworks into personalized vaccine prediction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.