ArticleJournal of veterinary internal medicine
Descriptive Analysis and Factors Associated With Relapse in Dogs With Presumptive Idiopathic Immune-Mediated Polyarthritis.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Descriptive Analysis and Factors Associated With Relapse in Dogs With Presumptive Idiopathic Immune-Mediated Polyarthritis.Journal of veterinary internal medicineArticle
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Authors and funding
13 authors.
Funding
Abstract
backgroundImmune-mediated polyarthritis (IMPA) is a joint disease common in dogs. Although its prognosis is generally favorable, relapses are frequent, and predictive factors for relapse remain poorly characterized.
objectivesTo evaluate the outcome of medical management of IMPA in dogs and identify predictive factors for relapse. ANIMALS: Client-owned dogs diagnosed with non-associative IMPA between 2010 and 2022 across four veterinary referral centers.
methodsThis was a retrospective multicentric study. The data collected at the time of diagnosis, including signalment, clinical presentation, imaging, and laboratory findings, and treatments, were analyzed. Relapse was defined as the recurrence of clinical signs, CRP levels above the reference range, or both after remission. Associations with time from remission to relapse were assessed using univariate and multivariable Cox models.
resultsAmong 119 dogs, 114 (95.8%) achieved remission. Among the 85 dogs with relapse data, the median time to relapse was 6.5 months, with relapse rates of 43% at 6 months, 61% at 12 months, and 65% at 24 months. In the multivariable analysis, thrombocytosis (adjusted hazard ratio [aHR] = 5.5 [2.0-15.0]
conclusionThis study highlights a favorable clinical outcome for dogs with non-associative IMPA with high remission rates but substantial relapse risks. Lameness, lymphadenomegaly, and thrombocytosis are associated with a greater risk of relapse.
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