Evidence map›Paper›PMID 40910510›Full record

ArticleIUCrJ2025

Magellon - an extensible platform for cryo-EM data visualization, management and processing.

Behdad Khoshbin, Puneeth Damodar, Rupali R Garje, Frank H Schotanus, Nandagopal Nair, Lai Wei, Jan Hannes Schäfer, Gabriel C Lander, Michael A Cianfrocco, Scott M Stagg

Abstract read
In one paragraph

Article in IUCrJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection.Acta crystallographica. Section F, Structural biology communications · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Behdad KhoshbinInstitute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA.
Puneeth DamodarInstitute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA.
Rupali R GarjeDepartment of Computer Science, Florida State University, Tallahassee, FL, USA.ORCID 0009-0007-8349-2395
Frank H SchotanusInstitute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA.ORCID 0009-0002-0318-8419
Nandagopal NairInstitute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA.
Lai WeiLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Jan Hannes SchäferDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, USA.ORCID 0000-0001-8163-1629
Gabriel C LanderDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, USA.ORCID 0000-0003-4921-1135
Michael A CianfroccoLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Scott M StaggInstitute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA.ORCID 0000-0001-8855-4152

Funding

Automated, optimized, intelligent data collection for cryo-EMR01GM143805 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI LANDER, GABRIEL C · 2021 to 2025
$4.7M
NIGMS NIH HHS R01 GM143805
6 · The paper itself

Abstract

Single-particle cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling high-resolution determination of macromolecular structures. However, the field faces challenges in data management, processing workflow integration and software extensibility. We present Magellon, an innovative cryo-EM software platform that addresses these challenges through a modern microservices architecture. Magellon consists of an extensible backend with a web based frontend that we call Magellon Viewer. Together, these combine high-performance computing capabilities with an intuitive user interface, enabling researchers to efficiently process and analyze cryo-EM data. The platform's distinguishing features include a plugin based architecture, distributed processing capabilities, comprehensive monitoring systems, and a novel approach to data organization and visualization. A key philosophy of the approach is that the Magellon backend provides a platform that uses robust industry-standard libraries to orchestrate computational tasks while offering users and developers flexibility in selecting the computational resources for performing calculations. Magellon represents a significant advancement in cryo-EM software infrastructure, offering flexibility, scalability and extensibility while maintaining ease of use.

Indexed as

Cryoelectron MicroscopyData ManagementData VisualizationSoftwareUser-Computer Interfaceautomationcryo-EMdata processingmacromolecular structuresMagellonstructural biology

Identifiers

PMID40910510
PMCPMC12573927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.