ArticleInternational journal of cancer2026
Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses.
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Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses.International journal of cancer · 2026Article
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Authors and funding
75 authors.
Amy MooreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Eleanor KaneDepartment of Health Sciences, University of York, York, UK.
Lauren R TerasDepartment of Population Science, American Cancer Society, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-2419-8536
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Joshua AriasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Orestis A PanagiotouDepartment of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, Rhode Island, USA.
Alain MonnereauUnit of Mixed Research (UMR1153), Centre for Research in Epidemiology and Statistics (CRESS), INSERM, Université Paris-Cité, Paris, France.
Nicole Wong DooConcord Clinical School, University of Sydney, Concord, New South Wales, Australia.
Zhaoming WangDepartment of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0001-7556-3869
Susan L SlagerQuantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Roel C H VermeulenDepartment of Population Health Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
Claire M VajdicSurveillance and Evaluation Research Program, The Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-3612-8298
Karin E SmedbyDepartment of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
John J SpinelliCancer Control Research, BC Cancer, Vancouver, British Columbia, Canada.
Joseph VijaiDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Brian K LinkDepartment of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Alan A ArslanDepartment of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA.
Alexandra NietersCenter for Chronic Immunodeficiency, Institute for Immunodeficiency, University Medical Center Freiburg, Freiburg, Baden-Württemberg, Germany.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Nicola J CampDepartment of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Gilles SallesSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Wendy CozenDivision of Hematology-Oncology, Department of Medicine, University of California Irvine, Orange, California, USA.
Henrik HjalgrimDepartment of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark.
Immaculata De VivoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-7185-7402
Hans-Olov AdamiDepartment of Epidemiology, Harvard T H Chan School of Public Health, Boston, Massachusetts, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Nikolaus BeckerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany.
Yolanda BenaventeCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, Barcelona, Spain.
Simonetta BisanziRegional Laboratory for Cancer Prevention, Institute for Cancer Research, Prevention and Oncological Network (ISPRO), Florence, Italy.
Paolo BoffettaStony Brook Cancer Center, Stony Brook University, Stony Brook, New York, USA.ORCID https://orcid.org/0000-0002-3811-2791
Paul BrennanGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC), Lyon, France.
Angela R Brooks-WilsonGenome Sciences Centre, BC Cancer, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0003-1009-6408
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID https://orcid.org/0000-0002-4261-4583
Jacqueline ClavelUnit of Mixed Research (UMR1153), Centre for Research in Epidemiology and Statistics (CRESS), INSERM, Université Paris-Cité, Paris, France.
Lucia CondeBill Lyons Informatics Centre, UCL Cancer Institute, University College London, London, UK.
David G CoxCancer Research Center of Lyon, INSERM U1052, Centre Léon Bérard, Lyon, France.
Karen CurtinDepartment of Internal Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Hervé GhesquièresDepartment of Hematology, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre Benite, France.
Bengt GlimeliusDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Thomas M HabermannDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Jonathan N HofmannDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Mark LiebowDepartment of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Anne LincolnSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Marc MaynadieINSERM U1231, EA 4184, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon, France.
James McKayGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC), Lyon, France.
Mads MelbyeDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Lucia MiligiEnvironmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy.
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Thierry J MolinaDepartment of Pathology, APHP, Necker and Robert Debré, Université Paris Cité, Institut Imagine, INSERM U1163, Paris, France.
Lindsay M MortonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Kenneth OffitSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Marina PadoanUnit of Medical Statistics and Epidemiology, Department Translational Medicine, University of Eastern Piedmont "Amedeo Avogadro", Novara, Italy.
Sara PiroEnvironmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy.
Alpa V PatelSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Vignesh RavichandranSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Elio RiboliCancer Epidemiology and Prevention Research Unit, School of Public Health, Imperial College London, London, UK.
Richard K SeversonDepartment of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan, USA.
Melissa C SoutheyCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-6313-9005
Anthony StainesSchool of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland.
Lesley F TinkerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, DC, USA.
Ruth C TravisCancer Epidemiology Unit, University of Oxford, Oxford, UK.
Sophia S WangDivision of Health Analytics, City of Hope Beckman Research Institute, Duarte, California, USA.
Elisabete WeiderpassGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC), Lyon, France.
Stephanie WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Tongzhang ZhengDepartment of Epidemiology, Brown University, Providence, Rhode Island, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Brenda M BirmannChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
James R CerhanLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-7482-178X
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0001-5230-0652
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MWomen's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8MUTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6MViral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0MThe Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI HOUTMAN, JON C.D. · 2002 to 2021
$45.7MMayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2MRESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MCancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0MBIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
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Abstract
Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05-1.33, p = .005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (OR
Indexed as
Body Mass IndexLymphoma, Large B-Cell, DiffuseMultifactorial InheritanceObesityAdiposityCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLeukemia, Lymphocytic, Chronic, B-CellLymphoma, FollicularMaleMendelian Randomization AnalysisMiddle AgedPolymorphism, Single Nucleotide
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