Evidence map›Paper›PMID 40910464›Full record

ArticleJournal of clinical pharmacology2025

A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite.

Yunjiao Wu, Swantje Völler, Sebastiaan C Goulooze, Karel Allegaert, Catherine M T Sherwin, Anne van Rongen, Daniëlla W E Roofthooft, Sinno H P Simons, Dick Tibboel, Robert B Flint and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yunjiao WuDivision of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Swantje VöllerDivision of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Sebastiaan C GouloozeLeiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P) Consultants BV, Leiden, The Netherlands.
Karel AllegaertDepartment of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-9921-5105
Catherine M T SherwinInternal Medicine, UWA Medical School, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-0844-3207
Anne van RongenDivision of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Daniëlla W E RoofthooftDepartment of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.
Sinno H P SimonsDepartment of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.
Dick TibboelDepartment of Pediatric Surgery, Erasmus University MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Robert B FlintDepartment of Pediatrics, Division of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.
John N van den AnkerDivision of Clinical Pharmacology, Children's National Hospital, Washington, DC, USA.
Catherijne A J KnibbeDivision of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.ORCID 0000-0001-9893-4415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A preterm and term neonate to adult (PTNA) maturation equation was introduced recently to describe the glomerular filtration rate maturation from birth to adulthood for neonates of varying gestational age. This study aims to evaluate the newly developed PTNA equation against common maturation approaches like allometric scaling (AS0.75), the AS0.75 plus postmenstrual age (PMA)-based E

Indexed as

AcetaminophenAnalgesics, Non-NarcoticLiverModels, BiologicalAdolescentAdultChildChild, PreschoolFemaleGestational AgeHumansInfantInfant, NewbornInfant, PrematureMaleMetabolic Clearance RateAcetaminophenAnalgesics, Non-Narcoticglucuronidationmaturationoxidationparacetamolpreterm neonatessulfation

Identifiers

PMID40910464
PMCPMC12649303

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.