Evidence map›Paper›PMID 40910449›Full record

Observational studyMovement disorders : official journal of the Movement Disorder Society2025

Abnormal Connectivity of the Head Neural Integrator in Cervical Dystonia.

Giuseppe A Zito, Emmanuel Roze, Clément Tarrano, Salim Ouarab, Prasanthi Jegatheesan, Asya Ekmen, Benoît Béranger, Romain Valabregue, Cécile Hubsch, Sophie Sangla and 11 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03351218 (Neuronal Correlates of Agency in Dystonia), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03351218 nacompletednot on this map

Neuronal Correlates of Agency in Dystonia

TypeinterventionalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2017 to 2022Enrolled76ConditionsDystonia, PrimaryArmsBehavioral testing - computerized tasks
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Giuseppe A ZitoSwiss Paraplegic Research, Nottwil, Switzerland.ORCID https://orcid.org/0000-0002-5027-884X
Emmanuel RozeMovement Investigation and Therapeutics Team, Sorbonne Université, INSERM U1127, CNRS UMR 7225, Paris Brain Institute, Paris, France.ORCID https://orcid.org/0000-0001-9727-3459
Clément TarranoMovement Investigation and Therapeutics Team, Sorbonne Université, INSERM U1127, CNRS UMR 7225, Paris Brain Institute, Paris, France.ORCID https://orcid.org/0000-0001-5627-2126
Salim OuarabCenter for NeuroImaging Research (CENIR), Paris Brain Institute, Sorbonne University, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, Paris, France.
Prasanthi JegatheesanMovement Investigation and Therapeutics Team, Sorbonne Université, INSERM U1127, CNRS UMR 7225, Paris Brain Institute, Paris, France.
Asya EkmenMovement Investigation and Therapeutics Team, Sorbonne Université, INSERM U1127, CNRS UMR 7225, Paris Brain Institute, Paris, France.
Benoît BérangerCenter for NeuroImaging Research (CENIR), Paris Brain Institute, Sorbonne University, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, Paris, France.ORCID https://orcid.org/0000-0003-0704-9854
Romain ValabregueCenter for NeuroImaging Research (CENIR), Paris Brain Institute, Sorbonne University, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, Paris, France.ORCID https://orcid.org/0000-0002-1814-9570
Cécile HubschService de Neurologie, CHUV Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-9091-7087
Sophie SanglaService de Neurologie, Hôpital de la Fondation Rothschild, Paris, France.
Cécilia BonnetMovement Investigation and Therapeutics Team, Sorbonne Université, INSERM U1127, CNRS UMR 7225, Paris Brain Institute, Paris, France.
Cécile DelormeAssistance Publique - Hôpitaux de Paris, DMU Neurosciences, Paris, France.
Aurélie MéneretMovement Investigation and Therapeutics Team, Sorbonne Université, INSERM U1127, CNRS UMR 7225, Paris Brain Institute, Paris, France.ORCID https://orcid.org/0000-0002-7623-1142
Bertrand DegosNeurology Unit, AP-HP, Avicenne University Hospital, Bobigny, France.ORCID https://orcid.org/0000-0001-5644-1292
Floriane BouquetDepartment of Neurology, Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.
Marion Apoil BrissardPolyclinique du Parc, Université de Caen Normandie, Caen, France.
Marie VidailhetMovement Investigation and Therapeutics Team, Sorbonne Université, INSERM U1127, CNRS UMR 7225, Paris Brain Institute, Paris, France.ORCID https://orcid.org/0000-0002-2409-9143
Dominique HasbounMovement Investigation and Therapeutics Team, Sorbonne Université, INSERM U1127, CNRS UMR 7225, Paris Brain Institute, Paris, France.ORCID https://orcid.org/0000-0003-4672-236X
Pierre PougetMovement Investigation and Therapeutics Team, Sorbonne Université, INSERM U1127, CNRS UMR 7225, Paris Brain Institute, Paris, France.ORCID https://orcid.org/0000-0002-4721-7376
Yulia Worbe *Movement Investigation and Therapeutics Team, Sorbonne Université, INSERM U1127, CNRS UMR 7225, Paris Brain Institute, Paris, France.ORCID https://orcid.org/0000-0001-5903-9370
Cécile Gallea *Movement Investigation and Therapeutics Team, Sorbonne Université, INSERM U1127, CNRS UMR 7225, Paris Brain Institute, Paris, France.ORCID https://orcid.org/0000-0001-8070-8794

Funding

Agence Nationale de la Recherche ANR-16-CE37-0003-03AmadysFondation Brou de LaurièreMerz PharmaceuticalsSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung P400PM_183958Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung P5R5PM_203160/1
6 · The paper itself

Abstract

backgroundCervical dystonia is characterized by abnormal neck and head movements, possibly related to a dysfunction of the interstitial nucleus of Cajal (INC) and the head neural integrator, a system responsible for the control of head and eye movements. However, neuroanatomical evidence of alterations in the head neural integrator in cervical dystonia is sparse.

objectivesWe investigated structural and functional integrity of the INC and its connections in cervical dystonia.

methodsThis cross-sectional, observational study compared 19 cervical dystonia patients and 21 healthy controls, using anatomical, diffusion-weighted, and resting-state functional images. We reconstructed tracts converging on the INC, and involved in the control of head movements. We evaluated group differences in microstructural integrity using fixel-based analysis, and effective connectivity using dynamic causal modeling.

resultsCompared with controls, patients showed microstructural abnormalities within the INC and cerebral peduncle. Effective connectivity showed abnormal self-inhibition in the INC, substantia nigra, and vermis in patients, with decreased excitation from the substantia nigra to the INC, increased inhibition from the deep cerebellar nuclei and primary sensorimotor cortex, and decreased excitation from the INC to the cerebellar vermis.

conclusionsA dysfunction of the INC might contribute to altered sensorimotor integration in cervical dystonia, and abnormal feedback from its afferent connections could alter its integrative function, resulting in a disturbed head and neck posture. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

HeadHead MovementsTorticollisAdultAgedCross-Sectional StudiesDiffusion Magnetic Resonance ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural Pathwaysbrainstemdynamic casual modelsfixel‐based analysisinterstitial nucleus of Cajal

Identifiers

PMID40910449
PMCPMC12661620

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.