Evidence map›Paper›PMID 40910433›Full record

Trial reportEuropean journal of pain (London, England)2025

Does Adding Electroanalgesic Modalities to a Multimodal Therapeutic Program Improve Clinical Outcomes in Individuals With Chronic Nonspecific Neck Pain? A Randomised Controlled Trial.

Gabriela Nascimento de Santana, Aron Charles Barbosa da Silva, Patrícia Gabrielle Dos Santos, Carlos Eduardo Girasol, Adriano Rodrigues de Oliveira, Almir Vieira Dibai-Filho, Cid André Fidelis de Paula Gomes

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in European journal of pain (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05400486 (Comparison of the Additional Effects of Using TENS and Interferential Currents for the Treatment of Individuals With Chronic Nonspecific Neck Pain.), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05400486 nacompletednot on this map

Comparison of the Additional Effects of Using TENS and Interferential Currents for the Treatment of Individuals With Chronic Nonspecific Neck Pain.

TypeinterventionalSponsorUniversity of Nove de JulhoRan2022 to 2025Enrolled75ConditionsNeck Pain, Chronic PainArmsTherapeutic exercise, Therapeutic exercise group + high frequency TENS, Therapeutic exercise group + Interferential
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gabriela Nascimento de SantanaPostgraduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo, Brazil.
Aron Charles Barbosa da SilvaPostgraduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo, Brazil.
Patrícia Gabrielle Dos SantosPostgraduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo, Brazil.
Carlos Eduardo GirasolDepartment of Physics, Faculty of Philosophy, Sciences and Letters, University of São Paulo, São Paulo, Brazil.
Adriano Rodrigues de OliveiraPostgraduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo, Brazil.
Almir Vieira Dibai-FilhoPostgraduate Program in Rehabilitation and Functional Performance, Federal University of Maranhão, São Luís, Brazil.
Cid André Fidelis de Paula GomesPostgraduate Program in Rehabilitation Sciences, Nove de Julho University, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-6627-7537

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic nonspecific neck pain (CNSNP) is a prevalent and complex condition. Although many studies have evaluated the effectiveness of transcutaneous electrical nerve stimulation (TENS), interferential current (IFC), therapeutic exercise (TE), and manual therapy (MT) individually, this study aimed to determine whether adding IFC and/or TENS to a Multimodal Therapeutic Intervention Program (MTIP) would produce better outcomes than the MTIP alone concerning functional capacity, pain intensity, pain catastrophising, kinesiophobia and overall perceived effect in individuals with CNSNP.

methodsSeventy-five individuals with CNSNP were randomly assigned to one of three groups: MTIP, MTIP + IFC, or MTIP + TENS. Interventions were conducted over 8 weeks. Outcomes were assessed at baseline, post-intervention, and at a 1-month follow-up. The primary outcome was the Neck Disability Index (NDI). Secondary outcomes included the Numeric Pain Rating Scale (NPRS) at rest and during movement, the Pain-Related Catastrophizing Thoughts Scale (PRCTS), the Tampa Scale for Kinesiophobia (TSK), the Copenhagen Neck Functional Disability Scale (CNFDS), the WHO Disability Assessment Schedule (WHODAS 2.0), and the Global Perceived Effect Scale (GPES).

resultsNo significant differences were observed between groups for the primary outcome. For secondary outcomes, the MTIP group showed improved results for NPRS-m and CNFDS. Additionally, MTIP was superior to MTIP + IFC for NPRS-r post-intervention, while MTIP + TENS outperformed both groups at follow-up. No significant differences were found for GPES, and none of the differences reached clinical significance.

conclusionsThe addition of IFC and/or TENS to an MTIP did not enhance clinical outcomes in individuals with CNSNP. SIGNIFICANCE: The results of this study assist clinicians in making informed decisions regarding the selection of therapeutic resources for managing chronic nonspecific neck pain. They also support researchers in refining and conducting new studies focused on improving the implementation of multimodal intervention protocols. Additionally, these findings help individuals with chronic nonspecific neck pain better understand which interventions may be most appropriate to include in their rehabilitation process.

trial registrationNCT05400486.

Indexed as

Chronic PainMusculoskeletal ManipulationsNeck PainPain ManagementTranscutaneous Electric Nerve StimulationAdultCatastrophizationCombined Modality TherapyExercise TherapyFemaleHumansMaleMiddle AgedPain MeasurementTreatment Outcome

Identifiers

PMID40910433
PMCPMC12412195

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.