ArticleInternational journal of molecular medicine2025
Piezo knockdown reduces 5‑hydroxytryptamine release from enterochromaffin cells and exacerbates intestinal dyskinesia in mice with functional constipation.
Article in International journal of molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Kernel Fatty Oils ofNutrients · 2026Article
- Piezo1 in digestive homeostasis and disease: Barrier function, immune signalling, cellular injury and metabolism.Clinical and translational medicine · 2026Review
- Piezo ion channels in the digestive system: Mechanotransduction pathways and therapeutic targeting strategies.Genes & diseases · 2026Review
- Dysregulation of the HSF1-Mediated UPRBiomolecules · 2026Article
- Gut Microbiota-Mediated Modulation of Intestinal Serotonin by Tea Polyphenols: Potential Mechanisms and Implications for Metabolic Health.Nutrients · 2026Review
- Modulation of the Mechanosensory Matrisome by Serotonergic Signaling.Results and problems in cell differentiation · 2026Review
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Authors and funding
11 authors.
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Abstract
Enterochromaffin (EC) cell dysfunction decreases 5‑hydroxytryptamine (5‑HT) secretion, contributing to functional constipation (FC). However, the underlying mechanisms remain unclear. Piezo ion channels mediate 5‑HT release from EC cells. The present study investigated the roles and mechanisms of Piezo1 and Piezo2 in the pathogenesis of FC and explored possible interactions. In a loperamide‑induced FC mouse model, Piezo1 and Piezo2 were singly or simultaneously knocked down using adeno‑associated viruses. In vitro, their function in EC cells was assessed via lentiviral‑mediated knockdown in the QGP‑1 cell line. In FC mice, the expression of Piezo1 and Piezo2, along with their colocalization with EC cells, was significantly reduced. Knockdown of either channel impaired intestinal motility, prolonged gastrointestinal transit time, delayed gastric emptying and reduced small intestinal propulsion. Correspondingly, 5‑HT, 5‑HT
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