Evidence map›Paper›PMID 40910091›Full record

ReviewNeuropsychiatric disease and treatment2025

Vitamin Interventions in ASD and ADHD: Systematic Review and Meta-Analysis.

Yonghui Shen, Yangbing Xie, Yadan Zheng, Yanbin Zheng, Yan Liu

Abstract readReview
In one paragraph

Review in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yonghui Shen *Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Yangbing Xie *Department of Psychiatry, Jiande Fourth People's Hospital, Jiangde, Zhejiang, China.
Yadan ZhengCollege of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Yanbin ZhengCollege of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Yan LiuAffiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vitamin interventions have emerged as a cost-effective and accessible approach to managing Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD), primarily for alleviating gastrointestinal symptoms such as constipation. Recent studies suggest vitamins may also improve core symptoms, yet most existing research focuses on comparisons between patients and healthy controls, lacking clinically relevant, evidence-based insights. Methods: A meta-analysis was conducted using studies retrieved from PubMed, Web of Science, and the Cochrane Library, focusing on vitamin interventions in ASD and ADHD populations. Results: The findings indicate that vitamin supplementation significantly improves symptoms in both ASD and ADHD. However, the effects vary by vitamin type and disorder. Vitamin B supplementation was particularly effective in reducing ASD-related symptoms, while vitamin D supplementation showed greater efficacy in improving ADHD symptoms. Conclusion: Different vitamins exert disorder-specific therapeutic effects, suggesting their potential role in guiding tailored clinical interventions for ASD and ADHD.

Indexed as

ADHDASDmeta-analysisvitamin therapy

Identifiers

PMID40910091
PMCPMC12407005

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.