Evidence map›Paper›PMID 40909944›Full record

ArticleFrontiers in oncology2025

Elevated FDG uptake in non-tumorous lung regions does not predict immune checkpoint inhibitor-related pneumonitis in lung cancer patients.

Friederike Völter, Lukas Wehlte, Blerina Resuli, Julia Walter, Lea Daisenberger, Maria Ingenerf, Maurice Heimer, Matthias Brendel, Gabriel T Sheikh, Lena M Unterrainer and 4 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Advances in Radiomics for Immune Checkpoint Inhibitor-related Pneumonitis 
of Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Friederike VölterDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Lukas WehlteDepartment of Medicine V, LMU University Hospital, Munich, Germany.
Blerina ResuliGerman Center for Lung Research (Deutsches Zentrum für Lungenforschung (DZL)) (Comprehensive Pneumology Center - Munich (CPC-M)), Munich, Germany.
Julia WalterGerman Center for Lung Research (Deutsches Zentrum für Lungenforschung (DZL)) (Comprehensive Pneumology Center - Munich (CPC-M)), Munich, Germany.
Lea DaisenbergerDepartment of Dermatology and Allergy, LMU University Hospital, Munich, Germany.
Maria IngenerfDepartment of Radiology, LMU University Hospital, Munich, Germany.
Maurice HeimerDepartment of Radiology, LMU University Hospital, Munich, Germany.
Matthias BrendelDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Gabriel T SheikhDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Lena M UnterrainerDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Diego Kauffmann-GuerreroGerman Center for Lung Research (Deutsches Zentrum für Lungenforschung (DZL)) (Comprehensive Pneumology Center - Munich (CPC-M)), Munich, Germany.
Thomas PflugerDepartment of Nuclear Medicine, LMU University Hospital, Munich, Germany.
Lucie HeinzerlingDepartment of Dermatology and Allergy, LMU University Hospital, Munich, Germany.
Amanda TufmanGerman Center for Lung Research (Deutsches Zentrum für Lungenforschung (DZL)) (Comprehensive Pneumology Center - Munich (CPC-M)), Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Predictors for checkpoint inhibitor-related pneumonitis (cinrPneumonitis) are desperately needed. This study aimed to investigate the pretreatment standardized uptake value (SUV) on [ Methods: All patients with lung cancer receiving [ Results: A total of 239 patients were included, of whom 41 (17.2%) developed cinrPneumonitis. The pretreatment radioligand uptake (SUV Conclusion: This is the largest study on the association of pretreatment radioligand uptake of the non-tumorous lung and the risk of a cinrPneumonitis. Our results showed no significant association between elevated pretreatment radioligand uptake of non-tumorous lung tissue on FDG-PET/CT and the development of cinrPneumonitis.

Indexed as

[18F]FDG-PET/CTcheckpoint inhibitor-related pneumonitischeckpoint inhibitor therapyimmune-related adverse eventslung cancerNSCLCSCLCstandardized uptake value

Identifiers

PMID40909944
PMCPMC12405330

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.