ArticleFrontiers in veterinary science2025
Associations between prepartum urine pH and periparturient blood calcium concentrations in multiparous Holstein cows.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Metabolic alkalosis induced by prepartum diet cations impairs Ca homeostasis in the periparturient cow. Adding anions to prepartum diets reduces blood pH improving periparturient Ca homeostasis. Urine pH generally reflects blood pH and is practical to measure on farm. The degree to which urine should be acidified to increase periparturient blood Ca concentration is not well defined. Materials and methods: Prepartum urine pH and periparturient blood Ca concentrations determined in 660 multiparous Holstein cows from 9 studies were analyzed. Least Square Means of the lowest blood Ca concentration (Ca nadir) observed in cows within 6 urine pH categories (≤ 5.75, 5.76 to 6.25, 6.26 to 6.75, 6.76 to 7.25, 7.26 to 7.75, and ≥ 7.76) were determined. Data were analyzed across all 660 cows and then by parity. Results: Across all cows, the Ca nadir was lowest and the incidence of cows with Ca nadir < 2.00 mM, indicative of subclinical hypocalcemia (SCH), was greatest when urine pH was ≥ 7.76. Mean Ca nadir increased in all cows with urine pH < 7.75. There was no significant difference in Ca nadir or % of cows with SCH when prepartum urine pH was < 7.75. This was also the case for 2nd and 3rd parity cows. However, in ≥ 4th parity cows, those with urine pH between 6.26 and 6.75 had significantly higher Ca nadir than cows with urine pH above 7.25 or below 5.75. Calcium nadir and blood Ca concentrations at 2 days in milk (DIM) were highly correlated (r = + 0.58), and blood Ca concentrations at 2 and 4 DIM were moderately correlated (r = + 0.43). Blood Ca concentration at 4 DIM was weakly associated with Ca nadir (r = + 0.30). Discussion: These analyses support acidification of cows to achieve prepartum urine pH below 7.75 to increase blood Ca nadir for 2nd and 3rd parity cows. For ≥ 4th parity cows, the highest blood Ca nadir was observed with urine pH below 7.25 and above 5.75. For ≥ 4th parity cows, urine pH below 5.75 was associated with significantly lower blood Ca nadir.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.