ReviewFrontiers in microbiology2025
Neuroplasticity and the microbiome: how microorganisms influence brain change.
Review in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Sex hormones, the gut microbiome, and neurodegenerative diseases: Lifespan perspective.Neural regeneration research · 2026Article
- Superoxide dismutase and glutathione interact to determine cognitive outcome among people with subjective cognitive decline (SCD): a prospective study.European archives of psychiatry and clinical neuroscience · 2026Article
- Review
- Microbiome-Informed Precision Electroconvulsive Therapy: Oral-Gut-Immune Signatures and Seizure Biology as Candidate Predictors of Response-A Narrative Review.Biomedicines · 2026Review
- Article
- Intranasal Delivery of Bacterial Extracellular Vesicles Enables RNA Cargo Entry Into the Brain.Journal of extracellular vesicles · 2026Article
- Early Gut Microbiota and Neurodevelopmental Trajectories: Implications for Pediatric Neuropsychiatric Vulnerability-A Narrative Review.Nutrients · 2026Review
- Dietary Polyphenols in Brain Aging: Molecular Mechanisms and Implications for Neurodegeneration.Nutrients · 2026Review
- Probiotics as Modulators of Adult Neurogenesis and Synaptic Plasticity: New Perspectives in the Pathophysiology and Treatment of Affective Disorders.Biomedicines · 2026Review
- Progesterone Receptor Expression in the Human Enteric Nervous System.International journal of molecular sciences · 2026Article
- From cooperation to collapse: the diet-microbiota-host gene triad in disease and aging.Frontiers in microbiomes · 2026Review
- Gut dysbiosis in neurodevelopmental disorders: linking microbiota signatures to cognitive rigidity in autism spectrum disorder.Frontiers in microbiology · 2026Review
- Potential value of oral Mogibacterium in major depressive disorder.Frontiers in cellular and infection microbiology · 2026Article
- Gut Microbiota and Autism: Unlocking Connections.Nutrients · 2025Review
- The Endocannabinoid-Microbiota-Neuroimmune Super-System: A Unifying Feedback Architecture for Systems Resilience, Collapse Trajectories, and Precision Feedback Medicine.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroplasticity, the brain's ability to reorganize and adapt, has traditionally been attributed to external stimuli, learning, and experience. However, emerging research highlights the gut microbiota as a key modulator of neuroplasticity through the gut-brain axis. This review examines the mechanisms by which intestinal microorganisms influence brain function, including microbial metabolite production, immune system modulation, neurotransmitter synthesis, and hormonal regulation. Dysbiosis, or microbial imbalance, has been linked to neurodevelopmental disorders, major depressive disorder (MDD), and cognitive impairments, emphasizing the microbiome's role in psychiatric and neurological health. Animal and human studies suggest that microbiota-targeted interventions, such as probiotics, prebiotics, and dietary modifications, may enhance neuroplasticity and mitigate mental health disorders. Future research should focus on understanding direct microbial-neuronal interactions and developing personalized microbiome-based therapies. This study underscores the gut microbiota's potential as a novel target for improving brain plasticity and mental health outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.