ArticleDrug design, development and therapy2025
Effectiveness and Safety of Anlotinib-Related Therapeutic Regimens in Patients with Previously Immune Checkpoint Inhibitors-Treated Advanced NSCLC: A Real-World Exploratory Study.
Article in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Effectiveness and Safety of PD-1 Inhibitor Rechallenge After Prior Immunotherapy in Patients Aged ≥ 60 Years with Advanced Non-Small-Cell Lung Cancer: A Single-Center Retrospective Study.Drugs - real world outcomes · 2026Article
- Article
- Health behaviors and symptom clusters mediate self-management efficacy and quality of life in lung cancer immunotherapy.Scientific reports · 2026Article
- Real-World Outcomes and Safety of PD-1 Blockade Rechallenge Strategies After Prior Immunotherapy in Advanced NSCLC: A Retrospective Cohort Study.Drug design, development and therapy · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to identify the effectiveness and safety of anlotinib-related therapeutic regimens in patients with previously immune checkpoint inhibitors (ICIs)-treated advanced non-small cell lung cancer (NSCLC). Methods: A total of 107 patients with previously ICIs-treated advanced NSCLC who received anlotinib-related regimens or single-agent chemotherapy in clinical practice were included in this study retrospectively. The anlotinib group (AG) included 54 patients who received anlotinib-related regimens, and the chemotherapy group (CG) consisted of 53 patients who received single-agent chemotherapy. This study retrospectively collected the efficacy and safety data during the patients' therapeutic process and performed regular follow-up to obtain long-term survival data. Clinical outcomes and safety profiles between AG and CG were analyzed and compared. Results: Best overall response of the 107 patients with previously ICIs-treated advanced NSCLC suggested that objective response rates of AG and CG were 24.1% and 11.3%, respectively; no statistically significant difference was observed ( Conclusion: Among patients with previously ICIs-treated advanced NSCLC, anlotinib-related therapeutic regimens demonstrated encouraging efficacy and a tolerable safety profile compared with the single-agent chemotherapy regimen. This conclusion still needs further validation in prospective clinical trials.
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