ArticleFrontiers in nutrition2025
Early-life nutritional supplementation protects against home environmental risks in Ghanaian children's social-emotional development.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00970866 (Efficacy of Lipid-based Nutrient Supplements), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Efficacy of Lipid-based Nutrient Supplements (LNS) for Pregnant and Lactating Women and Their Infants
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Authors and funding
11 authors.
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Abstract
Introduction: This study examines how an early-life small-quantity lipid-based nutrient supplement (LNS) interacts with the home environment to influence Ghanaian children's social-emotional functioning at preschool age. Method: In a randomized controlled trial, 1,320 Ghanaian women received either daily LNS, multiple micronutrients (MMN) or iron and folic acid (IFA) during pregnancy through 6 months postpartum. Infants in the LNS group received the daily supplement from 6 to 18 months. The IFA and MMN groups were combined to be the control group. At 4-6 years ( Results: Both LNS and higher quality home environments-particularly caregiver responsivity and negative behavior acceptance-predicted children having fewer social-emotional difficulties. LNS supplementation moderated relations between the home environment and children's hyperactivity/inattention and total difficulties. Living in a safer physical environment was related to fewer hyperactivity/inattention problems and total difficulties only for children who received LNS. Less academic stimulation was related to more hyperactivity/inattention only for children in the control group. Conclusion: Early-life LNS supplementation and supportive home environments reduce social-emotional difficulties in Ghanaian children. Nutritional interventions are most effective in the context of safe, stimulating households, demonstrating that integrated interventions support children's wellbeing in low- and middle-income countries. Clinical trial registration: clinicaltrials.gov; identifier: NCT00970866.
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