ArticleFrontiers in nutrition2025
Glucose and lipid metabolism in non-diabetic, non-obese patients with obstructive sleep apnea: sex differences.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The mediating role of cardiac autonomic imbalance in the association between hypoxic burden and dyslipidemia in obstructive sleep apnea.Annals of medicine · 2026Article
- Differential associations of lipid profile and genetic susceptibility with sleep duration.Lipids in health and disease · 2026Article
- Beyond the Apnea-Hypopnea Index: Circulating Biomarkers and Device-Based Metrics for Cardiometabolic Risk Stratification in Obstructive Sleep Apnea.Journal of clinical medicine · 2026Review
- Glucose-lipid metabolic dysregulation and sleep fragmentation in obstructive sleep apnea: insights from a large-scale cross-sectional study and exploratory hypoxia-related single-nucleus transcriptomic analysis.Frontiers in nutrition · 2026Article
- Obstructive sleep apnea as a modifier of endocrine toxicities associated with immune checkpoint inhibitors in lung cancer.Frontiers in immunology · 2026Review
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Authors and funding
5 authors.
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Abstract
Objective: Obstructive sleep apnea (OSA) is associated with glucose and lipid disturbances and insulin resistance. However, glucose and lipid disturbances and insulin resistance in OSA are often attributed to confounding obesity and/or diabetes. Studies on nondiabetic, nonobese OSA patients are very limited. Methods: This cross-sectional study retrospectively analyzed non-diabetic, non-obese adults who underwent a home sleep apnea testing and collected fasting blood samples before or after the sleep study to measure glucose and lipids. This study was designed as a cross-sectional study and therefore can only demonstrate associations between variables, but not causality. Results: Among the 191 participants (mean age 48.94 years, 68.06% male) included in the study, 83.77% had OSA. The high-density lipoprotein cholesterol (HDL-C) level in OSA participants was significantly lower (0.99 vs. 1.12 mmol/L, Conclusion: Our study supports the claim that there are sex differences in glucose and lipid metabolic disorders in non-diabetic, non-obese OSA participants: women mainly showed elevated fasting plasma glucose and TyG index, while men showed dyslipidemia with elevated triglycerides and decreased HDL-C. These findings highlight the need to consider sex differences when assessing OSA-related metabolic risks.
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