ArticlemedRxiv : the preprint server for health sciences2025
Hemispheric atrophy as a predictor for naming recovery following left hemisphere ischemic stroke.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Numerous large-scale epidemiological studies investigating the trajectory of cognitive recovery after ischemic stroke have presented data suggesting an immediate drop in cognition acutely post-stroke followed by persistent, accelerated decline over time when averaged as a group. We sought to further examine this trend, speculating that the average persistent decline may be a reflection of two subgroups with vastly different prognoses: 1) a minority experiencing decline secondary to neurodegenerative processes like vascular dementia and Alzheimer's disease, and 2) a majority without marked progressive brain atrophy who typically see improvement. Our team thus investigated atrophy's association with language recovery, hypothesizing that declining naming performance in the year after left hemisphere ischemic stroke would be correlated to atrophy of the contralesional hemisphere. We postulated that volume loss within the lesioned hemisphere would be less informative due to separate confounding processes related to the stroke itself like Wallerian degeneration and encephalomalacia. Participants (
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