Evidence map›Paper›PMID 40909842›Full record

ArticlemedRxiv : the preprint server for health sciences2025

In Vivo Mechanical Assessment of Cortical Bone Rigidity Enhances Fracture Discrimination Beyond DXA in Postmenopausal Women.

Brian C Clark, Todd M Manini, Janet E Simon, Leatha A Clark, Charalampos Lyssikatos, Stuart J Warden

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Brian C ClarkOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University.
Todd M ManiniDepartment of Health Outcomes and Biomedical Informatics, University of Florida.
Janet E SimonOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University.
Leatha A ClarkOhio Musculoskeletal and Neurological Institute (OMNI), Ohio University.
Charalampos LyssikatosIndiana Center for Musculoskeletal Health, Indiana University School of Medicine.
Stuart J WardenIndiana Center for Musculoskeletal Health, Indiana University School of Medicine.ORCID 0000-0002-6415-4936

Funding

Resource CoreP30AR072581 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Sharon M Moe · 2017 to 2026
$8.3M
Development of Cortical Bone Mechanics Technology for Enhancing the Diagnosis of OsteoporosisR44AG058312 · NIA · OSTEODX INC. · PI CLARK, BRIAN C, DICK, ANDREW · 2021 to 2024
$4.0M
NIAMS NIH HHS P30 AR072581NIA NIH HHS R44 AG058312
6 · The paper itself

Abstract

Dual-energy x-ray absorptiometry (DXA)-derived areal bone mineral density (BMD) remains the clinical standard for assessing osteoporosis risk, yet it fails to identify over 75% of individuals who sustain fragility fractures. Direct in vivo mechanical assessment of cortical bone strength may address this diagnostic gap by capturing structural and material properties that govern whole-bone strength but are not reflected by BMD. We conducted a multicenter case-control study with cross-sectional assessment to compare ulna flexural rigidity, a biomechanical property correlated with whole-bone strength (R

Indexed as

Bone Mineral DensityCortical boneCortical Bone Mechanics TechnologyDXAFlexural rigidityFragility fractureMechanical strengthOsteoporosis diagnosisRisk stratification

Identifiers

PMID40909842
PMCPMC12407662

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.