ArticleResearch square2025
Target Engagement in a Head-to-head Clinical Trial of Dysphoric versus Anxiosomatic TMS Targets.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
Funding
Abstract
Functional connectivity (FC) is increasingly used to measure target engagement following transcranial magnetic stimulation (TMS), but whether FC changes are specific to the TMS target remains unclear. We examined FC before and after TMS in patients with depression and anxiety (N=29) enrolled in a randomized trial targeting a dysphoric vs. anxiosomatic circuit. We tested whether: 1) TMS selectively modulated FC within the targeted circuit; 2) baseline TMS site FC to the targeted circuit predicted FC changes; 3) either metric correlated with symptom improvement. We found that: 1) FC decreased in both circuits, but effects were not clearly target-specific; 2) FC to the targeted circuit correlated with FC changes; 3) FC to the targeted circuit, not FC changes, correlated with symptom improvement. Results were driven by the anxiosomatic target group, likely due to heterogeneity in dysphoric circuit properties. These results have implications for using FC to target TMS and measure engagement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.