Evidence map›Paper›PMID 40909806›Full record

ArticleResearch square2025

A Crowdsourced Megastudy of 12 Digital Single-Session Interventions for Depression in American Adults.

Benjamin Kaveladze, Jan Voelkel, Michael Stagnaro, Mingjing Huang, Amanda Smock, Erin Sullivan, Yao Xu, Madison McCall, Juan Pablo Zapata, Syed Ishtiaque and 39 more

Registry-linked trialAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06856668 (A Megastudy of Single-Session Interventions to Challenge Depression in American Adults), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06856668 nacompletednot on this map

A Megastudy of Single-Session Interventions to Challenge Depression in American Adults

TypeinterventionalSponsorNorthwestern UniversityRan2025 to 2025Enrolled7,505ConditionsDepression - Major Depressive DisorderArmsBehavioral Activation (Action Brings Change Project 10-Minute Version), Mindful Acceptance, Moral Elevation, Mindful Attention Skills, 5 Habits to Beat Depression
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

49 authors.

Benjamin KaveladzeUniversity of California, Irvine, USA.
Jan VoelkelCornell University.
Michael StagnaroYale University.
Mingjing HuangNorthwestern University.
Amanda SmockNorthwestern University.
Erin SullivanCentral Connecticut State University.
Yao XuStanford University.ORCID https://orcid.org/0009-0009-3538-2671
Madison McCallUniversity of North Carolina at Chapel Hill.
Juan Pablo ZapataNorthwestern University.
Syed IshtiaqueUniversity of Toronto.
Ananya BhattacharjeeUniversity of Toronto.
Iva GeorgievaBulgarian Academy of Sciences.
Rosa Hernandez-RamosUniversity of California, Irvine.
Kenneth HuberCalm Health.
Julia JenningsUniversity of Texas at Austin.
Arianna KirkVisionari Media.
Rachel KornfieldNorthwestern University.
Robert KnowlesKoko.
Monika LindUniversity of California, Irvine.
Michelle LiuLoyola University Chicago.
Michael LiutUniversity of Toronto Mississauga.
Alex MariakakisUniversity of Toronto.
Ali MattuMind Stuff LLC.
Adam McGuireThe University of Texas at Tyler.ORCID https://orcid.org/0000-0002-4512-1207
Jonah MeyerhoffNorthwestern University Feinberg School of Medicine.ORCID https://orcid.org/0000-0001-5149-7959
Alissa MrazekThe University of Texas at Austin.
Michael MrazekThe University of Texas at Austin.
David MohrNorthwestern University.ORCID https://orcid.org/0000-0002-5443-7596
Robert MorrisKoko.
Christopher MosunicCalm Health.
Hana NipUniversity of California, Irvine.
Allen Olson-UrtechoStudio Bahia.
Jessa PodellThe University of Texas at Austin.
Dustyn RansomThe University of Texas at Austin.
Shireen RizviAlbert Einstein College of Medicine.
Matthew SouthwardThe Ohio State University.
Sarah Elizabeth StoecklUniversity of California, Irvine.
Madison TaylorUniversity of California, Irvine.
Amy TexterUniversity of Colorado Boulder.
Angelique TrotterThe University of Texas at Austin.
Calvin TowerThe University of Texas at Austin.ORCID https://orcid.org/0000-0002-1284-6228
Joseph WilliamsUniversity of Toronto.
Elijah WoodsonThe University of Texas at Austin.
Katherine WislockiUniversity of California, Irvine.
John ProtzkoCentral Connecticut State University.
Lorenzo Lorenzo-LuacesIndiana University Bloomington.
Stephen SchuellerUniversity of California Irvine.
Matthew NockHarvard University.
Jessica SchleiderNorthwestern University.

Funding

#EverythingSucks: Understanding the bidirectional relations between vulnerability to internalizing symptoms in youth (13-20) and social mediacontentR01MH135502 · NIMH · TRUSTEES OF INDIANA UNIVERSITY · PI Johan L. Bollen, Lorenzo Lorenzo Luaces · 2024 to 2026
$1.8M
mHealth for suicide prevention: Design, development, and feasibility of a scalable SMS-based safety planning interventionK08MH128640 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Jonah Meyerhoff · 2022 to 2026
$1.0M
NIMH NIH HHS K08 MH128640NIMH NIH HHS R01 MH135502
6 · The paper itself

Abstract

Digital self-guided single-session interventions (SSIs) provide a structured psychological intervention within one interaction. We crowdsourced 66 diverse 10-minute SSIs for depression and selected 11 for testing in a pre-registered "megastudy" (ClinicalTrials.gov ID: NCT06856668). American adults (N = 7,505) experiencing elevated depressive symptoms were recruited online and randomly assigned to one of the 11 crowdsourced SSIs, a previously-validated active comparison SSI, or a control without intervention content. Nearly all SSIs boosted agency and hope for improvement immediately after completion (ds ≤ 0.37). However, only two significantly reduced depression at four-week follow-up (ds = 0.14 and 0.15). Unexpectedly, some SSIs may have decreased readiness to change at four weeks (ds ≤ 0.14). The most successful SSIs provided focused, engaging, and actionable guidance on a skill that directly addressed users' struggles. Future work should aim to leverage SSIs' short-term gains to promote longer-term behavior change or service engagement.

Identifiers

PMID40909806
PMCPMC12408015

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.