Dynamic remodeling of the pancreas immune landscape in obesity.
Alexey Koshkin, Kranthi Kiran Kishore Tanagala, Anna Eichinger, Michael Chait, Aoife Young, Shanila Shakil, Junichi Yoshikawa, Yosuke Sakamoto, Steven B Wells, Xiaojuan Chen and 3 more
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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Obesity is a known risk factor for diseases of the pancreas, including diabetes, pancreatic cancer and pancreatitis, but mechanisms remain unclear. To elucidate how obesity impacts pancreatic immune homeostasis, we performed spatial, transcriptomic and functional profiling of human pancreatic immune cells from obese and non-obese organ donors. Obesity was associated with higher density of tissue resident memory T-cells (TRM) in the exocrine pancreas which display high cytotoxic functions and aggregated around macrophages. Single cell sequencing of pancreatic macrophages revealed two main subsets - FOLR2
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Dynamic remodeling of the pancreas immune landscape in obesity. · full record | OpenQuestion