Evidence map›Paper›PMID 40909779›Full record

ArticleResearch square2025

Strain-Level microbial signatures and inferred functional alterations in infants with Food Protein-Induced Allergic Proctocolitis.

Chen Goldstein, Itamar Lavy, Timothy Sun, Dena Ennis, Wayne G Shreffler, Qian Yuan, Yamini V Virkud, Victoria M Martin, Moran Yassour

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Chen GoldsteinThe Hebrew University of Jerusalem.
Itamar LavyThe Hebrew University of Jerusalem.
Timothy SunThe Hebrew University of Jerusalem.
Dena EnnisThe Hebrew University of Jerusalem.
Wayne G ShrefflerThe Hebrew University of Jerusalem.
Qian YuanThe Hebrew University of Jerusalem.
Yamini V VirkudThe Hebrew University of Jerusalem.
Victoria M MartinThe Hebrew University of Jerusalem.
Moran YassourThe Hebrew University of Jerusalem.

Funding

Endophenotypes of food allergy in response to oral immunotherapyK23AI130408 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI VIRKUD, YAMINI V · 2018 to 2022
$1.0M
Systems approach to elucidate the microbiome's influence on the development of food allergies early in lifeK23AI151556 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARTIN, VICTORIA MACKENZIE · 2021 to 2025
$998k
NIAID NIH HHS K23 AI130408NIAID NIH HHS K23 AI151556
6 · The paper itself

Abstract

The complex relationship between the gut microbiome and immune system development during infancy is thought to be a key factor in the rising rates of pediatric allergic diseases. Food protein-induced allergic proctocolitis (AP), the earliest identified form of non-IgE-mediated food allergy in infants, occurs at the mucosal surface where dietary proteins, intestinal microbes, and immune cells directly interact, and increases the risk for life threatening IgE-mediated food allergy, making it an important model for understanding early food allergic disease development. The question of how specific microbial compositions and functional pathways contribute to AP development and progression remains poorly understood. Here we show that infants with AP exhibit microbial compositions that differ from unaffected controls, characterized by enrichment of

Identifiers

PMID40909779
PMCPMC12408021

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.