Evidence map›Paper›PMID 40909754›Full record

ArticlebioRxiv : the preprint server for biology2025

Genome-edited retinal organoids restore host bipolar connectivity in the primate macula.

Atsuta Ozaki, Akihiro Kawai, Ryutaro Akiba, Satoko Okayama, Nobuhiko Ohno, Keisuke Kajita, Tomohiro Masuda, Satoshi Yokota, Shin-Ichiro Ito, Du Peiyan and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Atsuta OzakiDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.ORCID 0000-0002-2359-5604
Akihiro KawaiOphthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.
Ryutaro AkibaOphthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.
Satoko OkayamaLaboratory for Ultrastructural Research, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Nobuhiko OhnoDivision of Ultrastructural Research, National Institute for Physiological Sciences, Okazaki, Japan.
Keisuke KajitaDepartment of Ophthalmology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Tomohiro MasudaDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.
Satoshi YokotaDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.
Shin-Ichiro ItoDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.
Du PeiyanOphthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.
Kenta OnoueLaboratory for Ultrastructural Research, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Shigenobu YonemuraLaboratory for Ultrastructural Research, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Mineo KondoDepartment of Ophthalmology, Mie University Graduate school of Medicine, Tsu, Japan.
Yasuo KurimotoDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.
Yingbin FuCullen Eye Institute, Baylor College of Medicine, Texas, USA.
Michiko MandaiDepartment of Ophthalmology, Kobe City Eye Hospital, Kobe, Japan.

Funding

A two-pronged approach to generating novel models of photoreceptor degeneration for regenerative cell therapyU24EY033272 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Yingbin Fu · 2021 to 2026
$3.8M
NEI NIH HHS U24 EY033272
6 · The paper itself

Abstract

Retinal organoids (ROs) represent a promising regenerative strategy for restoring vision in retinal degenerative diseases, but whether host cone bipolar cells (BCs) in the primate macula can rewire with transplanted photoreceptors remains unresolved. Here, we transplanted genome-edited human retinal organoids lacking ON-BCs (

Identifiers

PMID40909754
PMCPMC12407709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.