Evidence map›Paper›PMID 40909735›Full record

ArticlebioRxiv : the preprint server for biology2025

HEIP1 orchestrates pro-crossover protein activity during mammalian meiosis.

Arnaud De Muyt, Sunkyung Lee, Sushil Khanal, Laurine Dal Toe, Céline Adam, Raphael Mercier, Valérie Borde, Neil Hunter, Thomas Robert

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Arnaud De MuytCentre de Biologie Structurale (CBS), Univ Montpellier, CNRS, INSERM, 34090 Montpellier, France.
Sunkyung LeeHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Sushil KhanalHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.
Laurine Dal ToeCentre de Biologie Structurale (CBS), Univ Montpellier, CNRS, INSERM, 34090 Montpellier, France.
Céline AdamInstitut Curie, PSL University, Sorbonne Université, CNRS UMR3244, Dynamics of Genetic Information, 75248, Paris, France.
Raphael MercierDepartment of Chromosome Biology, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany.ORCID 0000-0001-6508-6608
Valérie BordeInstitut Curie, PSL University, Sorbonne Université, CNRS UMR3244, Dynamics of Genetic Information, 75248, Paris, France.
Neil HunterHoward Hughes Medical Institute, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0003-1498-2327
Thomas RobertCentre de Biologie Structurale (CBS), Univ Montpellier, CNRS, INSERM, 34090 Montpellier, France.ORCID 0000-0002-2458-7454

Funding

Roles of BRCA2 in Mammalian Meiosis and Gamete QualityR01HD109322 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NEIL HUNTER, Wolf-Dietrich Heyer · 2024 to 2026
$2.0M
NICHD NIH HHS R01 HD109322
6 · The paper itself

Abstract

Meiotic crossovers are needed to produce genetically balanced gametes. In mammals, crossover formation is mediated by a conserved set of pro-crossover proteins via mechanisms that remain unclear. Here, we characterize a mammalian pro-crossover factor HEIP1. In mouse HEIP1 is essential for crossing over and fertility of both sexes. HEIP1 promotes crossing over by orchestrating the recruitment of other pro-crossover proteins, including the MutS

Identifiers

PMID40909735
PMCPMC12407729

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.