Evidence map›Paper›PMID 40909734›Full record

ArticlebioRxiv : the preprint server for biology2025

Cotranslational folding and maturation of HIV-1 protease.

Justin Westerfield, Felix Nicolaus, Ronald Swanstrom, Gunnar von Heijne

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Justin WesterfieldDepartment of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden.ORCID 0000-0002-3937-5833
Felix NicolausDepartment of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden.ORCID 0000-0001-9230-8544
Ronald SwanstromDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.ORCID 0000-0001-7777-0773
Gunnar von HeijneDepartment of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden.ORCID 0000-0002-4490-8569

Funding

Integration of Evolution to Avoid Resistance in Structure Based Drug DesignR01GM135919 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHIFFER, CELIA A. · 2020 to 2023
$2.5M
NIGMS NIH HHS R01 GM135919
6 · The paper itself

Abstract

HIV-1 particle assembly depends critically on multiple proteolytic cleavages of viral polyproteins by the viral protease, PR. PR is translated as part of the Gag-Pro-Pol polyprotein, which undergoes autoproteolysis to liberate active, dimeric PR during virus particle maturation. Gag-Pro-Pol is produced via an infrequent -1 frameshifting event in ribosomes translating full length genomic RNA as Gag mRNA. Here, we study the cotranslational folding and autoproteolytic processing of frameshifted transframe-protease-reverse transcriptase (TF-PR-RT) constructs by

Indexed as

cotranslational foldingHIV-1 proteasematuration

Identifiers

PMID40909734
PMCPMC12407942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.