Evidence map›Paper›PMID 40909728›Full record

ArticlebioRxiv : the preprint server for biology2025

Distinct modes of evolution drive HIV escape from two broadly neutralizing antibodies.

Elena V Romero, Abigail E Clyde, Elena E Giorgi, Dylan H Westfall, Walker Azam, Megan L Taylor, Marina Caskey, Alison F Feder, Lillian B Cohn

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Elena V RomeroDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2631-3289
Abigail E ClydeVaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-7256-1259
Elena E GiorgiVaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0003-2968-1033
Dylan H WestfallVaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-2434-8525
Walker AzamVaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0009-0002-2613-3576
Megan L TaylorDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0009-0002-2511-1498
Marina CaskeyLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-1727-8693
Alison F FederDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2915-089X
Lillian B CohnVaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID 0000-0002-3485-8692

Funding

Defining the mechanisms of HIV resistance to bNAbs in humansU01AI169385 · NIAID · ROCKEFELLER UNIVERSITY · PI Marina Caskey · 2022 to 2026
$7.8M
A phylodynamic time machine for solid tumorsDP2CA280623 · NCI · UNIVERSITY OF WASHINGTON · PI FEDER, ALISON F · 2022 to 2025
$2.3M
NCI NIH HHS DP2 CA280623NIAID NIH HHS U01 AI169385
6 · The paper itself

Abstract

Broadly neutralizing antibodies (bNAbs) show promise for HIV treatment and prevention, but are vulnerable to resistance evolution. Comprehensively understanding

Identifiers

PMID40909728
PMCPMC12407991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.