Evidence map›Paper›PMID 40909714›Full record

ArticlebioRxiv : the preprint server for biology2025

Ergosterol-depleted clinical isolates of

Alexander M Aldejohann, Nadja Thielemann, Aina Martinez Zurita, Christoph Müller, Tom Gräfenhan, Richard Kriz, Heimo Lagler, Isabell S Behr, Nathalie Reus, Annika Schöninger and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Alexander M AldejohannInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Nadja ThielemannInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Aina Martinez ZuritaInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.ORCID 0000-0001-9300-872X
Christoph MüllerDepartment of Pharmacy-Center for Drug Research, Ludwig Maximilians University Munich, Munich, Germany.
Tom GräfenhanCore Unit Systems Medicine, University of Würzburg, Würzburg, Germany.
Richard KrizDivision of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Heimo LaglerDivision of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-3240-7385
Isabell S BehrInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Nathalie ReusInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Annika SchöningerInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Grit WaltherNational Reference Center for Invasive Fungal Infections, Leibniz Institute for Natural Product Research and Infection Biology- Hans Knoell Institute, Jena, Germany.
Lena-Marie MazanInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Hannah WilhelmInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Birgit WillingerDivision of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-7921-5749
Christina A CuomoInfectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.ORCID 0000-0002-5778-960X
Oliver KurzaiInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.ORCID 0000-0002-7277-2646
Ronny MartinInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.ORCID 0000-0002-2212-1511

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI SABETI, PARDIS CHRISTINE · 2014 to 2024
$66.5M
NIAID NIH HHS U19 AI110818
6 · The paper itself

Abstract

Objectives: Methods: Whole-genome sequencing and sterol profiling were performed on nine clinical Results: Loss of function mutations in the genes Conclusions: These findings demonstrate that ergosterol depletion in

Identifiers

PMID40909714
PMCPMC12407835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.