Evidence map›Paper›PMID 40909684›Full record

ArticlebioRxiv : the preprint server for biology2025

Lipid composition determines thermotropic properties of meibum of animals and humans with Meibomian gland disorders.

Igor A Butovich, Jadwiga C Wojtowicz, Amber Wilkerson, Seher Yuksel

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Igor A ButovichDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jadwiga C WojtowiczDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Amber WilkersonDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Seher YukselDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Funding

Meibogenesis in Health, Disease, and Aging - Administrative SupplementR01EY027349 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI BUTOVICH, IGOR A · 2017 to 2025
$2.9M
NEI NIH HHS R01 EY027349
6 · The paper itself

Abstract

Meibum - a lipid-rich secretion produced by holocrine Meibomian glands (MG) - plays a central role in maintaining ocular surface homeostasis. Previously, changes in MG lipidomes induced by inactivation of critical genes of meibogenesis, such as

Indexed as

chromatography/mass spectrometrydifferential scanning microcalorimetryMeibomian gland dysfunctionMeibomian glandsmeibum

Identifiers

PMID40909684
PMCPMC12407770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.