Evidence map›Paper›PMID 40909673›Full record

ArticlebioRxiv : the preprint server for biology2025

The spike tip protein of bacteriophage T4.

Yves Mattenberger, Ekaterina S Knyazhanskaya, Mikhail M Shneider, Sergey A Buth, Sergey Nazarov, William P Robins, Petr G Leiman, Dominique Belin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yves MattenbergerDpt of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, CH-1211 Geneva, Switzerland.ORCID 0000-0002-1651-7691
Ekaterina S KnyazhanskayaDepartment of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, 77555-0647, USA.ORCID 0000-0001-6161-4223
Mikhail M ShneiderShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.ORCID 0000-0002-3768-3541
Sergey A ButhEmory University, School of Medicine, Department of Pediatrics Infectious Diseases, 2015 Uppergate Dr., Children's Center Bldg., Atlanta, Georgia 30322.ORCID 0000-0003-1922-0866
Sergey NazarovDubochet Center for Imaging Lausanne, EPFL and UNIL, EPFL VPA DCI-Lausanne, 1015, Lausanne, Switzerland.ORCID 0000-0002-5240-5849
William P RobinsDepartment of Microbiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Petr G LeimanDepartment of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, 77555-0647, USA.ORCID 0000-0002-9091-0918
Dominique BelinPrevious affiliation: Dpt of Pathology and Immunology, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, CH-1211 Geneva, Switzerland.ORCID 0000-0003-4686-339X

Funding

Structural and functional determinants of decision-making in bacteriophage host recognitionR01GM139034 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LEIMAN, PETR G · 2020 to 2023
$1.7M
NIGMS NIH HHS R01 GM139034
6 · The paper itself

Abstract

Contractile injection systems (CISs) - bacteriophage tails, tailocins, and bacterial type VI secretion systems - penetrate the envelope of the target cell by employing a contractile sheath-rigid tube mechanism. The membrane-attacking end of the tube carries a spike-shaped complex that ends with a spike tip. In bacteriophage P2, the spike and spike tip proteins are fused, and we used this phage to show that sheath contraction results in the translocation of the spike into the periplasm of the host cell. In bacteriophage T4, the spike and spike tip proteins are encoded by different genes. We show that the ORFan gene

Identifiers

PMID40909673
PMCPMC12407873

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.