Evidence map›Paper›PMID 40909654›Full record

ArticlebioRxiv : the preprint server for biology2025

Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI.

Mohamed I Barmada, Erin N McGinity, Suparno Nandi, Debayan Dey, Natalia Zelinskaya, George M Harris, Lindsay R Comstock, Christine M Dunham, Graeme L Conn

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Mohamed I BarmadaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.
Erin N McGinityDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.
Suparno NandiDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.
Debayan DeyDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.
Natalia ZelinskayaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.
George M HarrisDepartment of Chemistry, Wake Forest University, Winston-Salem, North Carolina, 27106, USA.
Lindsay R ComstockDepartment of Chemistry, Wake Forest University, Winston-Salem, North Carolina, 27106, USA.
Christine M DunhamDepartment of Chemistry, Emory University, Atlanta, Georgia, 30322, USA.ORCID 0000-0002-8821-688X
Graeme L ConnDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, 30322, USA.ORCID 0000-0002-2419-380X

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
NCCAT: National Center for CryoEM Access and TrainingR24GM154192 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI EDWARD T ENG, Jeffrey S Kieft · 2024 to 2026
$21.0M
RNA modification and antibiotic resistanceR01AI088025 · NIAID · EMORY UNIVERSITY · PI Graeme L Conn, Christine M Dunham · 2010 to 2026
$7.9M
Training Program in Biochemistry, Cell and Molecular BiologyT32GM135060 · NIGMS · EMORY UNIVERSITY · PI Lawrence H. Boise, ANITA H. CORBETT · 2020 to 2026
$2.8M
Intrinsic Ribosomal Decoding Center Methylation and the Bacterial Antibiotic ResponseF31AI186518 · NIAID · EMORY UNIVERSITY · PI MOHAMED I BARMADA · 2024 to 2026
$148k
NIAID NIH HHS F31 AI186518NIAID NIH HHS R01 AI088025NIGMS NIH HHS R24 GM154192NIGMS NIH HHS T32 GM135060NIGMS NIH HHS U24 GM129539
6 · The paper itself

Abstract

Ribosomal RNA (rRNA) modifications are important for ribosome function and can influence bacterial susceptibility to ribosome-targeting antibiotics. The universally conserved 16S rRNA nucleotide C1402, for example, is the only 2'-

Indexed as

30S subunithelix 44methylationmethyltransferaseRibosomesubstrate recognition

Identifiers

PMID40909654
PMCPMC12407886

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.