Evidence map›Paper›PMID 40909616›Full record

ArticlebioRxiv : the preprint server for biology2025

Gut mucin fucosylation dictates the entry of botulinum toxin complexes.

Sho Amatsu, Takuhiro Matsumura, Chiyono Morimoto, Sunanda Keisham, Yoshiyuki Goto, Tomoko Kohda, Jun Hirabayashi, Kengo Kitadokoro, Takane Katayama, Hiroshi Kiyono and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Sho AmatsuDepartment of Bacteriology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa 920-8640, Japan.ORCID 0000-0003-0692-264X
Takuhiro MatsumuraDepartment of Bacteriology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa 920-8640, Japan.
Chiyono MorimotoDepartment of Bacteriology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa 920-8640, Japan.
Sunanda KeishamCellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8560, Japan.
Yoshiyuki GotoDivision of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan.
Tomoko KohdaDepartment of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Metropolitan University, Osaka 598-8531, Japan.
Jun HirabayashiInstitute for Glyco-core Research (iGCORE), Nagoya University, Aichi 464-0814, Japan.
Kengo KitadokoroFaculty of Molecular Chemistry and Engineering, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.
Takane KatayamaGraduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Hiroshi KiyonoDepartment of Human Mucosal Vaccinology, Chiba University Hospital, Inohana, Chuo-ku, Chiba 260-8670, Japan.
Hiroaki TatenoCellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8560, Japan.
Masahiko ZukaDepartment of Forensic Medicine and Pathology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa 920-8640, Japan.
Yukako FujinagaDepartment of Bacteriology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa 920-8640, Japan.

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
CYTOKINE RESPONSES TO H PYLORI INFECTION OR IMMUNIZATIONR01DK051677 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ERNST, PETER B · 1997 to 2006
$1.5M
NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK051677
6 · The paper itself

Abstract

Botulinum toxins (BoNTs) are the most potent known bacterial toxins. The BoNT complex from

Indexed as

botulinum toxin complexClostridium botulinumhemagglutininlectinMucinMucus barrierα1,2-fucosylation

Identifiers

PMID40909616
PMCPMC12407859

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.