ArticlebioRxiv : the preprint server for biology2025
Ventral Pallidum GABA Neuron Inhibition Augments Context-Appropriate Defensive Responses to Learned Threat Cues.
Erica M Ramirez, Maricela X Martinez, Ryan K Rokerya, Vanessa Alizo Vera, Christina M Ruiz, Mitchell R Farrell, Shreeya A Walawalkar, Grace J Kollman, Stephen V Mahler
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Erica M RamirezDepartment of Neurobiology & Behavior, University of California, Irvine. 1203 McGaugh Hall, Irvine, CA 92697, USA.ORCID 0009-0002-7596-3592 Maricela X MartinezDepartment of Neurobiology & Behavior, University of California, Irvine. 1203 McGaugh Hall, Irvine, CA 92697, USA.ORCID 0000-0002-9540-2437 Ryan K RokeryaDepartment of Neurobiology & Behavior, University of California, Irvine. 1203 McGaugh Hall, Irvine, CA 92697, USA.
Vanessa Alizo VeraDepartment of Neurobiology & Behavior, University of California, Irvine. 1203 McGaugh Hall, Irvine, CA 92697, USA.ORCID 0000-0002-4561-2495 Christina M RuizDepartment of Neurobiology & Behavior, University of California, Irvine. 1203 McGaugh Hall, Irvine, CA 92697, USA.
Mitchell R FarrellDepartment of Neurobiology & Behavior, University of California, Irvine. 1203 McGaugh Hall, Irvine, CA 92697, USA.
Shreeya A WalawalkarDepartment of Neurobiology & Behavior, University of California, Irvine. 1203 McGaugh Hall, Irvine, CA 92697, USA.
Grace J KollmanDepartment of Neurosciences, University of California, 9375 Gilman Dr, San Diego, CA 92161, USA.
Stephen V MahlerDepartment of Neurobiology & Behavior, University of California, Irvine. 1203 McGaugh Hall, Irvine, CA 92697, USA.ORCID 0000-0002-8698-0905 Funding
Impact of Cannabinoid Across the Lifespan (ICAL)P50DA044118 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine M Gall · 2018 to 2026
$18.2MDynamic epigenomic landscape of opioid abuse following early-life adversityU01DA053826 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, CHRISTIE D FOWLER · 2022 to 2026
$3.4MVentral Pallidum Circuits Underlying Preclinical Models of Opioid AddictionR01DA055849 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Stephen Vincent Mahler · 2023 to 2026
$1.4MOn circuit mechanisms of reward behaviors after early-life adversityR01MH132680 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z., CHEN, YUNCAI · 2023 to 2024
$1.3MPersistent Impacts of Adolescent THC on Microglial Function and Opioid Addiction RiskF99NS141399 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARTINEZ, MARICELA XOCHIL · 2024 to 2025
$94kNIDA NIH HHS P50 DA044118NIDA NIH HHS R01 DA055849NIDA NIH HHS U01 DA053826NIMH NIH HHS R01 MH132680NINDS NIH HHS F99 NS141399
6 · The paper itselfAbstract
The ventral pallidum (VP) is embedded within the brain circuits controlling motivated behavior, which are heavily implicated in addiction and other psychiatric disorders. Prior work showed that VP GABAergic neurons (VP
Indexed as
Aversive MotivationDefensive TreadingFear ConditioningLateral HabenulaRats
Identifiers
PMID40909614
PMCPMC12407979
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