Evidence map›Paper›PMID 40909604›Full record

ArticlebioRxiv : the preprint server for biology2025

An estrogen-independent and IL-1-dependent pathway controls vulvovaginal candidiasis through combined IL-17/IL-22 signaling.

Bianca M Coleman, Melissa E Cook, Md Robin Khan, Amanda K Vogel, Anthony J Wells, Jian Miao, Shachi P Vyas, Tiffany C Taylor, Felix E Y Aggor, Nicole O Ponde and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Bianca M ColemanDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh PA 15261, USA.
Melissa E CookDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh PA 15261, USA.ORCID 0000-0002-2336-956X
Md Robin KhanGraduate Program in Pharmaceutical Sciences, College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis TN 38163.ORCID 0000-0002-8015-6819
Amanda K VogelIntegrated Program in Biomedical Sciences, College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis TN 38163.ORCID 0000-0001-7002-1278
Anthony J WellsDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis TN 38163.
Jian MiaoGraduate Program in Pharmaceutical Sciences, College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis TN 38163.ORCID 0000-0001-7013-3800
Shachi P VyasDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh PA 15261, USA.ORCID 0000-0003-2034-783X
Tiffany C TaylorDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh PA 15261, USA.ORCID 0000-0002-4971-3728
Felix E Y AggorDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh PA 15261, USA.ORCID 0000-0002-0327-0095
Nicole O PondeDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh PA 15261, USA.ORCID 0000-0003-2704-0451
Ipsita DeyDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh PA 15261, USA.
Henry ZouDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh PA 15261, USA.
Brian M PetersDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis TN 38163.ORCID 0000-0002-0445-2077
Sarah L GaffenDivision of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh PA 15261, USA.ORCID 0000-0001-8511-2041

Funding

Autoimmunity and Immunopathology Training ProgramT32AI089443 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHLOMCHIK, MARK J · 2010 to 2024
$6.6M
Candidalysin: a key mediator of Candida vaginitis immunopathologyR01AI134796 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Brian M Peters · 2018 to 2026
$2.9M
Mucosal host defense against vaginal candidiasisR21AI185365 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2024 to 2025
$434k
Anti-fungal immune responses in the female reproductive tractF32AI186291 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Melissa Erin Cook · 2024 to 2026
$155k
NIAID NIH HHS F32 AI186291NIAID NIH HHS R01 AI134796NIAID NIH HHS R21 AI185365NIAID NIH HHS T32 AI089443
6 · The paper itself

Abstract

Vulvovaginal candidiasis (VVC), caused by the commensal pathobiont

Indexed as

Candida albicanscytokine signalingfungal immunityIL-1mucosal candidiasisTh17vaginitis

Identifiers

PMID40909604
PMCPMC12407711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.