Evidence map›Paper›PMID 40909549›Full record

ArticlebioRxiv : the preprint server for biology2025

A molecularly defined basalo-prefrontal-thalamic circuit regulates sensory and affective dimensions of pain.

Guoguang Xie, Yiqiong Liu, Xuetao Qi, Aritra Bhattacherjee, Chao Zhang, Yi Zhang

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Guoguang XieHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.ORCID 0009-0007-7049-7648
Yiqiong LiuHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Xuetao QiHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Aritra BhattacherjeeHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
Chao ZhangHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.ORCID 0000-0003-4167-4872
Yi ZhangHoward Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.

Funding

Understanding neuronal subtype-specific function of NAc in cocaine addictionR01DA050589 · NIDA · BOSTON CHILDREN'S HOSPITAL · PI ZHANG, YI · 2021 to 2025
$3.7M
NIDA NIH HHS R01 DA050589
6 · The paper itself

Abstract

Both the medial prefrontal cortex (mPFC) and thalamus have been implicated in pain regulation. However, the roles of the mPFC-thalamus connection in pain and how the mPFC modulates nociceptive processing within the brain remain unclear. Here, we show that the mPFC neurons that project to thalamus are marked by

Indexed as

Foxp2-expressing neuronmPFCPainthalamus

Identifiers

PMID40909549
PMCPMC12407757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.