Evidence map›Paper›PMID 40909544›Full record

ArticlebioRxiv : the preprint server for biology2025

HP1β and H3K9me3 Regulate Olfactory Receptor Choice and Transcriptional Identity.

Martín Escamilla-Del-Arenal, Rachel Duffié, Hani Shayya, Valentina Loconte, Axel Ekman, Lena Annika Street, Adan Horta, Daniele Canzio, Kevin Monahan, Carolyn Larabell and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Martín Escamilla-Del-ArenalDepartment of Biochemistry and Molecular Biophysics, Mortimer B. Zuckerman Mind Brain and Behavior Institute Columbia University, Jerome L Greene Science Center, New York, NY 10027.
Rachel DuffiéDepartment of Biochemistry and Molecular Biophysics, Mortimer B. Zuckerman Mind Brain and Behavior Institute Columbia University, Jerome L Greene Science Center, New York, NY 10027.
Hani ShayyaDepartment of Biochemistry and Molecular Biophysics, Mortimer B. Zuckerman Mind Brain and Behavior Institute Columbia University, Jerome L Greene Science Center, New York, NY 10027.
Valentina LoconteDepartment of Anatomy, School of Medicine, University of California San Francisco, San Francisco, CA 94158, United States.
Axel EkmanDepartment of Anatomy, School of Medicine, University of California San Francisco, San Francisco, CA 94158, United States.
Lena Annika StreetDepartment of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027.
Adan HortaDepartment of Biochemistry and Molecular Biophysics, Mortimer B. Zuckerman Mind Brain and Behavior Institute Columbia University, Jerome L Greene Science Center, New York, NY 10027.
Daniele CanzioWeill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-2592-2269
Kevin MonahanDepartment of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Carolyn LarabellDepartment of Anatomy, School of Medicine, University of California San Francisco, San Francisco, CA 94158, United States.
Marko JovanovicDepartment of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027.
Stavros LomvardasDepartment of Biochemistry and Molecular Biophysics, Mortimer B. Zuckerman Mind Brain and Behavior Institute Columbia University, Jerome L Greene Science Center, New York, NY 10027.ORCID 0000-0002-7668-3026

Funding

How dynamic molecular interactions of RNA Binding Proteins drive post-transcriptional gene expression changesR35GM152258 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Marko Jovanovic · 2024 to 2026
$1.6M
NIGMS NIH HHS R35 GM152258
6 · The paper itself

Abstract

Diverse epigenetic regulatory mechanisms ensure and regulate cellular diversity. Among others, the histone 3 lysine 9 me3 (H3K9me3) post translational modification participates in silencing lineage-inappropriate genes. H3K9me3 restricts access of transcription factors and other regulatory proteins to cell-fate controlled genes. In mice, olfactory sensory neurons (OSN) express one olfactory receptor (OR) gene out of 2,600 possibilities. This monoallelic and stochastic OR choice happens as OSNs differentiate and undergo dramatic changes in nuclear architecture. OR genes from different chromosomes converge into specialized nuclear bodies and chromatin compartments as H3K9me3 and chromatin binding proteins including heterochromatin protein 1 (HP1) are incorporated. In this work, we have uncovered an unexpected role for HP1β in OR choice and neuronal identity that cannot be rescued by HP1α

Identifiers

PMID40909544
PMCPMC12407775

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.