ArticleFrontiers in medicine2025
Impact of bleeding and thrombosis on outcome of 945 COVID-19 VV-ECMO cases from a German registry.
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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
63 authors.
Johannes HerrmannDepartment of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Janno SchadeDepartment of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Patrick MeybohmDepartment of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Noah PaschkeDepartment of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Martha E HübschDepartment of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Quirin NotzDepartment of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Julie GroeneDepartment of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Daniel RöderDepartment of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Peter KrankeDepartment of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Michaela L MertenDepartment of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, ARDS and ECMO Center, Kliniken der Stadt Köln, Witten/Herdecke University Hospital, Cologne, Germany.
Micha LandollDepartment of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, ARDS and ECMO Center, Kliniken der Stadt Köln, Witten/Herdecke University Hospital, Cologne, Germany.
Peter SpiethDepartment of Anesthesiology and Intensive Care Medicine, University Hospital, Dresden at the TU Dresden, Dresden, Germany.
Stefan KlugeDepartment of Intensive Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Dominik JarczakDepartment of Intensive Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Kevin RoedlDepartment of Intensive Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Michael SonntagbauerDepartment of Intensive Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Christian PutensenDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.
Jens-Christian ScheweDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.
Stefan F EhrentrautDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.
Stefan KreyerDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.
Andreas WehrfritzDepartment of Anaesthesiology, University Hospital Erlangen, Friedrich-Alexander University, Erlangen- Nuernberg (FAU), Erlangen, Germany.
Ixchel CastellanosDepartment of Anaesthesiology, University Hospital Erlangen, Friedrich-Alexander University, Erlangen- Nuernberg (FAU), Erlangen, Germany.
Karl BihlmaierDepartment of Internal Medicine 4 - Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander University, Erlangen-Nuernberg (FAU), Erlangen, Germany.
Karsten SchmidtDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Thorsten BrennerDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Frank HerbstreitDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Florian EspeterDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Jan WiefhoffDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Richard K EllerkmannDepartment of Anesthesiologie and Intensive Care Medicine, Klinikum Dortmund, Klinikum University Witten/Herdecke, Dortmund, Germany.
Daniel OswaldDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, Clinic Centre Westfalen, Dortmund, Germany.
Björn EllgerDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, Clinic Centre Westfalen, Dortmund, Germany.
Gösta LotzDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe University Frankfurt, University Hospital Frankfurt, Frankfurt, Germany.
Florian J RaimannDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe University Frankfurt, University Hospital Frankfurt, Frankfurt, Germany.
Tobias WengenmayerDepartment of Cardiology and Angiology I (Heart Center Freiburg - Bad Krozingen), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Dawid L StaudacherDepartment of Cardiology and Angiology I (Heart Center Freiburg - Bad Krozingen), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Viviane ZotzmannInterdisciplinary Medical Intensive Care (IMIT), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Onnen MoererDepartment of Anesthesiology, University Medical Center Göttingen, Göttingen, Germany.
Christian KühnDepartment of Cardiothoracic, Transplanatation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Matthias KochanekCenter for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Ralf MuellenbachDepartment of Anesthesiology and Critical Care Medicine, ARDS/ECMO-Center, Campus Kassel of the University of Southampton, Kassel, Germany.
Patricia GlaserDepartement of Anaesthesia, perioperative Medicine and Interdisciplinary Intensive Care Medicine, ECLS/ECMO-Center, Asklepios Klinik Langen, Langen, Germany.
Falk FichtnerDepartment of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Center, Leipzig, Germany.
Marc BodensteinDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Michael FindeisenKlinik für Pneumologie, Internistische Intensiv- und Beatmungsmedizin, München Klinik Harlaching, Munich, Germany.
Vanessa RemboldKlinik für Pneumologie, Internistische Intensiv- und Beatmungsmedizin, München Klinik Harlaching, Munich, Germany.
Markus HeimDepartment of Anaesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, TUM School of Medicine and Health, Munich, Germany.
Gerhard SchneiderDepartment of Anaesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, TUM School of Medicine and Health, Munich, Germany.
Tobias LahmerDepartment of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, University of Munich, Munich, Germany.
Jan-Sören PadbergDepartment of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Muenster, Germany.
Carsten HullermannDepartment of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Muenster, Muenster, Germany.
Philipp M LepperDepartment of Internal Medicine V- Pneumology, Allergology and Critical Care Medicine, Saarland University, Homburg, Germany.
Andre P BeckerDepartment of Internal Medicine V- Pneumology, Allergology and Critical Care Medicine, Saarland University, Homburg, Germany.
Guy DanzigerDepartment of Internal Medicine V- Pneumology, Allergology and Critical Care Medicine, Saarland University, Homburg, Germany.
Carlos MetzDepartment of Internal Medicine V- Pneumology, Allergology and Critical Care Medicine, Saarland University, Homburg, Germany.
Peter RosenbergerDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.
Valbona MirakajDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.
Alice-Marie BernardDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.
Stephan BrauneDepartment of Medical Intensive Care and Emergency Medicine, St. Franziskus-Hospital Muenster, Münster, Germany.
Rebecca RothInstitute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
Anna GrauInstitute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
Peter HeuschmannInstitute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
Christian Karagiannidis *Department of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, ARDS and ECMO Center, Kliniken der Stadt Köln, Witten/Herdecke University Hospital, Cologne, Germany.
Christopher Lotz *Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bleeding and thromboembolic events (BTE) increase the mortality of COVID-19 acute respiratory distress syndrome (ARDS) treated with extracorporeal membrane oxygenation (ECMO). The current analysis aimed to assess frequency and determinants of BTE according to their location and severity in a retrospective analysis of the German ECMO COVID-19 registry. Logistic regression was applied to identify factors influencing ICU survival as well as variables associated with risks of BTE. In total, 708 of 945 patients (75%) suffered from BTE. Overall, 1,348 events were registered, including 406 (30%) major bleeding and 258 (19%) major thromboembolic events. Most common major bleeding locations were intracranial ( Clinical trial registration: Registered in the German Clinical Trials Register (study ID: DRKS00022964), retrospectively registered, September 7th 2020, https://drks.de/DRKS00022964.
Indexed as
acute respiraratory distress syndromebleedingCOVID-19extracorporeal membrance oxygenationthromboembolism
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.