ArticleFrontiers in pediatrics2025
Neurodevelopmental impact of early diagnostic imaging in preterm infants: quantifying risk and the role of point-of-care ultrasound.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Environmental exposures in the neonatal intensive care unit impacting neurodevelopmental outcomes for neonates.Pediatric research · 2025Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Medical imaging is essential in neonatal intensive care units (NICUs), particularly for the management of preterm infants. However, concerns persist regarding the neurodevelopmental impact of repeated low-dose radiation exposure. This study aimed to investigate whether cumulative x-ray exposure in the first month of life is associated with neurodevelopmental outcomes in preterm infants. Methods: We conducted a retrospective chart review of preterm infants (<34 weeks gestation) admitted to the Level IIIB NICU at Tufts Medical Center. Infants were included if they had at least one x-ray within the first 24 h of life and were followed consistently at the neurodevelopmental clinic till 12-18 months corrected age. Exclusion criteria included major congenital anomalies, severe perinatal complications and loss to follow-up. Cumulative x-ray exposure was recorded at Day 1, Day 7, and Month 1. Neurodevelopment was assessed using Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). Multiple linear regression analyses were used to assess associations, adjusting for gestational age, birth weight, comorbidities and SNAPPE-II scores. Results: Among 53 infants, cumulative imaging by Day 7 and Month 1 was significantly associated with lower Bayley-III motor and cognitive scores. Each additional x-ray by Day 7 was associated with a 1.38-point decline in motor scores ( Conclusion: Frequent x-ray exposure in the first month of life may be associated with worse motor and cognitive development in preterm infants. These findings suggest the need for weight-based diagnostic reference levels in NICUs and support incorporation of alternative imaging such as point of care ultrasound (POCUS into routine neonatal intensive care.
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