Evidence map›Paper›PMID 40909394›Full record

ArticleFrontiers in human neuroscience2025

Lateralized brain connectivity in auditory verbal hallucinations: fMRI insights into the superior and middle temporal gyri.

Vyara Zaykova, Sevdalina Kandilarova, Rositsa Paunova, Ferihan Popova, Drozdstoy Stoyanov

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Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Vyara ZaykovaDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria.
Sevdalina KandilarovaDepartment of Psychiatry and Medical Psychology, Research Institute and SRIPD-MUP, Translational and Computation Neuroscience Group, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria.
Rositsa PaunovaDepartment of Psychiatry and Medical Psychology, Research Institute and SRIPD-MUP, Translational and Computation Neuroscience Group, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria.
Ferihan PopovaDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria.
Drozdstoy StoyanovDepartment of Psychiatry and Medical Psychology, Research Institute and SRIPD-MUP, Translational and Computation Neuroscience Group, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Auditory verbal hallucinations are one of the most prevalent positive symptoms associated with schizophrenia. The superior and middle temporal gyri have been demonstrated to play a role in auditory and language perception. Dysfunction in the temporal cortex has been associated with the development of psychosis. The aim of the present study was to explore the functional connectivity and laterality of superior and middle temporal gyri in patients with auditory verbal hallucinations. Methods: Resting-state functional magnetic resonance imaging data was obtained from a total of 105 subjects including 63 healthy controls and 42 patients diagnosed with schizophrenia experiencing auditory verbal hallucinations. A comparative analysis was conducted to assess the functional connectivity of the superior and middle temporal gyri bilaterally. Results: The comparison between the two groups revealed several significant differences in the resting-state functional connectivity of the superior and middle temporal gyri in patients with auditory verbal hallucinations as compared to healthy controls. The aberrant connections were focused on the anterior part of the right superior temporal gyrus and the posterior part of the left one, as well as in the posterior division of the right middle temporal gyrus and both anterior and posterior divisions of the left middle temporal gyrus. Discussion: The observed dysconnectivity between the named subdivisions of the temporal lobe and cortical and subcortical structures suggests that the aberrant connectivity and brain lateralization may be related to the etiopathogenesis of schizophrenia and auditory verbal hallucinations.

Indexed as

auditory verbal hallucinationsfunctional connectivityfunctional magnetic resonance imagingmiddle temporal gyrusresting-stateschizophreniasuperior temporal gyrus

Identifiers

PMID40909394
PMCPMC12405222

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