Evidence map›Paper›PMID 40909363›Full record

ArticleWellcome open research2025

Digital mental health interventions for adolescents and young people (10-24 years) in Africa: A protocol for a systematic review of mental health outcomes, engagement, and equity considerations.

Aggrey Gisiora Mokaya, Nondumiso Michelle Dlamini, Syethemba Nkosi, Mpilonhle Thembinkosi Nzuza, Thandeka Smith, Grace Nduku Wambua, Xanthe Hunt, Alan Stein, Nothando Ngwenya

Abstract read
In one paragraph

Article in Wellcome open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aggrey Gisiora MokayaSocial Science, Africa Health Research Institute, Durban, KwaZulu-Natal, 4001, South Africa.ORCID https://orcid.org/0000-0002-6663-6330
Nondumiso Michelle DlaminiSocial Science, Africa Health Research Institute, Durban, KwaZulu-Natal, 4001, South Africa.
Syethemba NkosiSocial Science, Africa Health Research Institute, Durban, KwaZulu-Natal, 4001, South Africa.ORCID https://orcid.org/0000-0001-9174-2525
Mpilonhle Thembinkosi NzuzaSocial Science, Africa Health Research Institute, Durban, KwaZulu-Natal, 4001, South Africa.
Thandeka SmithSocial Science, Africa Health Research Institute, Durban, KwaZulu-Natal, 4001, South Africa.
Grace Nduku WambuaSocial Science, Africa Health Research Institute, Durban, KwaZulu-Natal, 4001, South Africa.
Xanthe HuntSocial Science, Africa Health Research Institute, Durban, KwaZulu-Natal, 4001, South Africa.ORCID https://orcid.org/0000-0001-7531-6665
Alan SteinSocial Science, Africa Health Research Institute, Durban, KwaZulu-Natal, 4001, South Africa.
Nothando NgwenyaSocial Science, Africa Health Research Institute, Durban, KwaZulu-Natal, 4001, South Africa.

Funding

Bill & Melinda Gates Foundation INV-033558Wellcome Trust
6 · The paper itself

Abstract

Background: Adolescents and young people (AYP) aged 10-24 years in Africa experience a high burden of mental health disorders but face significant barriers to accessing care, including a severe shortage of mental health professionals, stigma, and limited integration of mental health services into primary healthcare. Digital mental health interventions (DMHIs) offer a promising avenue to bridge these gaps by providing accessible, scalable, and potentially equitable support. However, little is known about the effectiveness, acceptability, and equity impacts of these interventions among African AYP. Objective: This systematic review aims to identify, characterize, and synthesize evidence on DMHIs targeting adolescents and young people in Africa, focusing on mental health outcomes, engagement, feasibility, and equity considerations. Methods: We will search PubMed, Scopus, Web of Science, and EBSCOhost databases, as well as the PsyberGuide repository, for empirical studies published between January 1, 2015, and April 3, 2025. Eligible studies must evaluate a digital mental health intervention among AYP aged 10-24 years living in Africa. Study designs will include randomized controlled trials, quasi-experimental studies, observational studies, and mixed-methods studies. Outcomes of interest include mental health symptom reduction (depression, anxiety, stress), psychological well-being, engagement, feasibility, acceptability, and equity-related factors such as gender inclusivity and digital access. Risk of bias will be assessed using RoB 2 and ROBINS-I tools, and evidence quality will be rated using the GRADE approach. Quantitative synthesis will be conducted where feasible, otherwise narrative synthesis will be employed. Conclusion: This review will provide a comprehensive synthesis of available evidence on DMHIs for adolescents and young people in Africa, offering critical insights into their effectiveness, feasibility, and contribution to promoting mental health equity. The findings aim to inform the development, implementation, and policy integration of digital mental health strategies tailored to young populations in diverse African contexts.

Indexed as

Digital mental health; mHealth; eHealth; Adolescents; Young adults; Youth mental health; Africa; Health equity; Mobile health interventions; Psychological well-being; Systematic review.

Identifiers

PMID40909363
PMCPMC12405850

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.