ArticleFrontiers in cellular and infection microbiology2025
Retrospective analysis of the impact of human papillomavirus infection in the male genital tract on sperm: from a single center.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Quality and content evaluation of male HPV infection on Bilibili and TikTok: a cross-sectional study.Scientific reports · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study primarily aimed to investigate human papillomavirus (HPV) infection in males and to evaluate its effect on semen parameters, fertility and partner HPV infection status. Methods: A total of 624 men who visited the West China Second Hospital of Sichuan University between October 1, 2019, and September 30, 2023, were included. HPV DNA was detected in exfoliated cells from the male genitalia using polymerase chain reaction (PCR) and reverse membrane hybridization to analyze the relationship between HPV infection and semen parameters. Furthermore, we retrospectively reviewed medical records of the participants and their partners to collect data on HPV infection and fertility outcomes. Results: The overall prevalence of HPV infection was 43.8% (273/624), with single-genotype infections accounting for a significantly higher proportion (59.3%, 162/273) than multiple-genotype infections (40.7%, 111/273). The five most prevalent HPV genotypes were HPV52, HPV16, HPV51, HPV58, and HPV42. High-risk (HR) genotypes accounted for most infections (79.5%, 217/273). Among 377 men who underwent semen analysis, HPV-positive individuals exhibited significantly reduced sperm motility and normal morphology compared to HPV-negative individuals (p<0.001). Furthermore, HPV infection was associated with increased sperm DNA fragmentation (p=0.007). Males co-infected with Ureaplasma urealyticum and Chlamydia trachomatis showed significantly lower total sperm counts (×10 Conclusion: Our findings indicate that male genital HPV infection is common and may adversely affect semen quality, fertility, and increase the risk of HPV transmission to sexual partners.
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