Evidence map›Paper›PMID 40909302›Full record

ArticleIJU case reports2025

A Case of Triplet Therapy Showing Remarkable Efficacy for Multiorgan Metastatic Recurrence After Radical Prostatectomy in Prostate Cancer.

Shuhei Kusano, Shohei Tobu, Minika Yukimoto, Yukako Yamaguchi, Yuka Kakinoki, Akihiro Maeda, Maki Kawasaki, Hiroaki Kakinoki, Mitsuru Noguchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IJU case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuhei KusanoDepartment of Urology, Faculty of Medicine, Saga University, Saga, Japan.ORCID https://orcid.org/0009-0002-1618-1646
Shohei TobuDepartment of Urology, Faculty of Medicine, Saga University, Saga, Japan.
Minika YukimotoDepartment of Urology, Faculty of Medicine, Saga University, Saga, Japan.
Yukako YamaguchiDepartment of Urology, Faculty of Medicine, Saga University, Saga, Japan.
Yuka KakinokiDepartment of Urology, Faculty of Medicine, Saga University, Saga, Japan.
Akihiro MaedaDepartment of Urology, Faculty of Medicine, Saga University, Saga, Japan.ORCID https://orcid.org/0000-0002-1829-4014
Maki KawasakiDepartment of Urology, Faculty of Medicine, Saga University, Saga, Japan.
Hiroaki KakinokiDepartment of Urology, Faculty of Medicine, Saga University, Saga, Japan.ORCID https://orcid.org/0000-0002-9460-8759
Mitsuru NoguchiDepartment of Urology, Faculty of Medicine, Saga University, Saga, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We report a case in which triplet therapy demonstrated efficacy for multiple metastatic recurrences following radical prostatectomy. Case Presentation: A 70-year-old man with relapsed metastatic castration-sensitive prostate cancer (mCSPC) following radical prostatectomy (Gleason 9, pT3bN1M0) presented with rectal involvement and extensive lymph node and bone metastases, as evidenced by a markedly elevated PSA level of 59.57 ng/mL. He received triplet therapy consisting of androgen deprivation therapy (ADT) with degarelix, darolutamide (1200 mg/day), and docetaxel (70 mg/m Conclusion: This case highlights the potential of triplet therapy as a highly effective treatment strategy for high-risk mCSPC patients who experience recurrence after initial local therapy.

Indexed as

degarelixdocetaxelmCSPCtriplet therapy darolutamide

Identifiers

PMID40909302
PMCPMC12408182

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.