Evidence map›Paper›PMID 40909236›Full record

ArticleNature reviews. Methods primers2023

Light-based vat-polymerization bioprinting.

Riccardo Levato, Oksana Dudaryeva, Carlos Ezio Garciamendez-Mijares, Bruce E Kirkpatrick, Riccardo Rizzo, Jacob Schimelman, Kristi S Anseth, Shaochen Chen, Marcy Zenobi-Wong, Yu Shrike Zhang

Abstract read
In one paragraph

Article in Nature reviews. Methods primers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Computational approaches in bioprinting processes.Nature reviews bioengineering · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Thiolated Polymers in 3D Bioprinting: Control of Gelation.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Riccardo LevatoDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
Oksana DudaryevaDepartment of Orthopedics, University Medical Center Utrecht, Utrecht, Netherlands.
Carlos Ezio Garciamendez-MijaresDivision of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA, USA.
Bruce E KirkpatrickDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0003-2862-3843
Riccardo RizzoDepartment of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland.
Jacob SchimelmanDepartment of NanoEngineering, University of California San Diego, La Jolla, CA, USA.
Kristi S AnsethDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, USA.
Shaochen ChenDepartment of NanoEngineering, University of California San Diego, La Jolla, CA, USA.
Marcy Zenobi-WongDepartment of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland.
Yu Shrike ZhangDivision of Engineering in Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA, USA.ORCID 0000-0002-0045-0808

Funding

Osteogenic Hydrogel Niches to Promote hMSC Migration and DifferentiationR01DE016523 · NIDCR · UNIVERSITY OF COLORADO AT BOULDER · PI ANSETH, KRISTI S. · 2005 to 2023
$6.2M
Synthetic hydrogels to study formation and maintenance of intestinal cryptsR01DK120921 · NIDDK · UNIVERSITY OF COLORADO · PI KRISTI S. ANSETH, PETER J DEMPSEY · 2019 to 2026
$3.8M
Bioprinting Plant Virus Nanoparticles for Immunotherapy and Relapse Prevention of Ovarian CancerR01CA253615 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN, FIERING, STEVEN · 2020 to 2024
$3.1M
High-throughput Imaging-integrated Vascular Model for Understanding Thromboembolism and Therapeutics ScreeningR01HL166522 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Junjie Yao, Y. Shrike Zhang · 2023 to 2026
$2.7M
Biomaterials for embolization and ablation of arterio-venous malformationsR01HL165176 · NHLBI · MAYO CLINIC ARIZONA · PI OKLU, RAHMI, ZHANG, Y. SHRIKE · 2022 to 2025
$2.6M
High-Throughput Volumetric Photoacoustic Imaging of Living Vascularized OrganoidsR01EB028143 · NIBIB · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2022
$2.0M
Rapid 3D-printing of Multi-functional Adaptive Nerve ConduitsR33HD090662 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2019 to 2021
$1.1M
Multiscale Stereolithogrphic Bioprinting of Stage-Matching Vascularized Tumor ModelsR21EB025270 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2018 to 2020
$726k
Studying Nanotoxicity Using Bioprinted Human Liver TissuesR21ES034455 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2022 to 2023
$398k
Rapid 3D Bioprinting of Cell-Laden Neurotrophic Factory Gradient Conduit for Neural Tissue Regeneration and Functional RecoveryF31NS125986 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHIMELMAN, JACOB BENJAMIN · 2022 to 2023
$60k
NCI NIH HHS R01 CA253615NHLBI NIH HHS R01 HL165176NHLBI NIH HHS R01 HL166522NIBIB NIH HHS R01 EB028143NIBIB NIH HHS R21 EB025270NICHD NIH HHS R33 HD090662NIDCR NIH HHS R01 DE016523NIDDK NIH HHS R01 DK120921NIEHS NIH HHS R21 ES034455NINDS NIH HHS F31 NS125986
6 · The paper itself

Abstract

Light-based vat-polymerization bioprinting enables computer-aided patterning of 3D cell-laden structures in a point-by-point, layer-by-layer or volumetric manner, using vat (vats) filled with photoactivatable bioresin (bioresins). This collection of technologies - divided by their modes of operation into stereolithography, digital light processing and volumetric additive manufacturing - has been extensively developed over the past few decades, leading to broad applications in biomedicine. In this Primer, we illustrate the methodology of light-based vat-polymerization 3D bioprinting from the perspectives of hardware, software and bioresin selections. We follow with discussions on methodological variations of these technologies, including their latest advancements, as well as elaborating on key assessments utilized towards ensuring qualities of the bioprinting procedures and products. We conclude by providing insights into future directions of light-based vat-polymerization methods.

Identifiers

PMID40909236
PMCPMC12407150

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.