Evidence map›Paper›PMID 40909069›Full record

ReviewCureus2025

Antidepressants and Lung Toxicity: A Narrative Review.

Ariana Azimi Shooshtari, Elakiya Anjali Jayaraman, Ramesh Kesavan, Siva Sarva, Skantha Manjunath, Azad Patel

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ariana Azimi ShooshtariCollege of Liberal Arts, University of Texas at Austin, Austin, USA.
Elakiya Anjali JayaramanCollege of Liberal Arts, University of Texas at Austin, Austin, USA.
Ramesh KesavanPulmonary and Critical Care Medicine and Internal Medicine, HCA Houston Healthcare Kingwood/University of Houston, Kingwood, USA.
Siva SarvaPulmonary and Critical Care Medicine and Internal Medicine, HCA Houston Healthcare Kingwood/University of Houston, Kingwood, USA.
Skantha ManjunathPulmonary and Critical Care Medicine, HCA Houston Healthcare Kingwood/University of Houston, Kingwood, USA.
Azad PatelPulmonary and Critical Care Medicine, HCA Houston Healthcare Kingwood/University of Houston, Kingwood, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary toxicity is a serious yet frequently under-recognized complication of antidepressant therapy. With the continued rise in prescriptions, awareness of potential respiratory adverse effects is crucial. This review outlines documented cases of lung injury linked to various antidepressant classes, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), atypical antidepressants, serotonin modulators, tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs). A wide range of manifestations, such as interstitial lung disease, eosinophilic pneumonia, acute respiratory distress syndrome, and alveolar hemorrhage, occurring at both standard dosages and in overdose situations, have been documented. Clinicians should remain vigilant for respiratory symptoms emerging during treatment and pursue timely evaluation and management to minimize the risk of long-term pulmonary complications and improve clinical outcomes.

Indexed as

acute respiratory distress syndrome (ards)antidepressantdrug-induced pneumonialung injurypsychotropic drugs

Identifiers

PMID40909069
PMCPMC12405962

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.