ReviewInternational journal of nanomedicine2025
Preparation Methods of Hydrogel Microspheres and Recent Advances in Their Application for Treating Diabetic Wounds.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Injectable microsphere-based delivery strategies for stem cells and their derivatives in tissue regeneration.Bioactive materials · 2026Review
- Regenerative Functional Microspheres for Aesthetic Medicine: Mechanism, Materials, Fabrication, and Clinical Applications.Advanced healthcare materials · 2026Review
- Compartmentalized Dual-Drug Injectable Hydrogel for Anti-Inflammatory Activity and Osteoarthritic Cartilage Repair.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Multifunctional Hydrogels for Diabetic Wound Healing: Design Strategies and Microenvironmental Remodeling Mechanisms.Gels (Basel, Switzerland) · 2026Review
- Anti-convulsant efficacy of long-acting injectable cannabidiol formulation (IVL5005) in the pentylenetetrazol-induced convulsions, with pharmacokinetic characterization.Frontiers in pharmacology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
Diabetic wounds are characterized by complex pathologies, such as vascular changes, nerve damage, and immune dysfunction, which make healing difficult. Hydrogel microspheres have shown great potential in the field of wound treatment due to their excellent biocompatibility, high water content, and soft physical properties. The review summarizes the preparation methods of hydrogel microspheres in detail, including microfluidic technology, spray method, electro spraying, emulsion method, phase separation, photomask method, and 3D printing technology. These methods have significant advantages in particle size control, morphological consistency, and functionalization. It then reviews the applications of hydrogel microspheres in the treatment of diabetic wounds, including the promotion of cell proliferation, migration, angiogenesis, and macrophage polarization, as well as precise treatment through controllable drug release and environmental responsiveness. In addition, the review explores the unique advantages of hydrogel microspheres in dealing with diabetic wounds complicated by infection and reviews the current challenges faced by these technologies in practical applications, such as preparation complexity, cost issues, and prospects for translation. Finally, the review looks forward to the future enhancement of hydrogel microsphere performance and application breadth through interdisciplinary research and new material development, providing more comprehensive and efficient solutions for the treatment of diabetic wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.