Evidence map›Paper›PMID 40908978›Full record

ArticleNeurology. Genetics2025

Vascular NOTCH3 Deposition Load: Association With

Yu-Wen Cheng, Chih-Hao Chen, Chi-Chao Chao, Ya-Fang Chen, Jiann-Shing Jeng, Sung-Chun Tang, Sung-Tsang Hsieh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Determinants of cerebral microbleed presence and burden in CADASIL.Cerebral circulation - cognition and behavior · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu-Wen ChengDepartment of Neurology, National Taiwan University Hospital, Taipei.ORCID https://orcid.org/0000-0002-3054-6333
Chih-Hao ChenDepartment of Neurology, National Taiwan University Hospital, Taipei.ORCID https://orcid.org/0000-0002-1258-8775
Chi-Chao ChaoDepartment of Neurology, National Taiwan University Hospital, Taipei.
Ya-Fang ChenDepartment of Medical Imaging, National Taiwan University Hospital, Taipei.ORCID https://orcid.org/0000-0003-2995-9189
Jiann-Shing JengDepartment of Neurology, National Taiwan University Hospital, Taipei.ORCID https://orcid.org/0000-0002-1456-3686
Sung-Chun TangDepartment of Neurology, National Taiwan University Hospital, Taipei.ORCID https://orcid.org/0000-0003-3731-5973
Sung-Tsang HsiehDepartment of Neurology, National Taiwan University Hospital, Taipei.ORCID https://orcid.org/0000-0002-3188-8482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Vascular NOTCH3 extracellular domain (NOTCH3ECD) deposition is the pathologic hallmark of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). We aimed to explore the relationships among the NOTCH3ECD deposition load, the Methods: Fifty-four individuals carrying Results: The NOTCH3ECD deposition load was greater in individuals with Discussion: The

Identifiers

PMID40908978
PMCPMC12406363

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.