ArticleJournal of inflammation research2025
Electroacupuncture Regulates Oxidative Stress-Mediated NLRP3/ASC/Caspase-1 Pathway to Inhibit Microglial Activation: Alleviating Neuroinflammation and Depression in IBD.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Microplastic-Induced Disruption of Intestinal Barrier Integrity and Triggering Neuroinflammatory Responses Through Gut-Brain Axis Dysregulation Mediated by NF-κB/PPAR-γ/BDNF Signalling Pathways.Molecular neurobiology · 2026Article
- Association of peripheral NLRP3 inflammasome activation with prevalent and incident chronic kidney disease in patients with obstructive sleep apnea: a prospective study.Sleep & breathing = Schlaf & Atmung · 2026Observational
- Neuron-tumor interplay in colorectal cancer: from mechanisms of onset and progression to targeted therapies.Cell communication and signaling : CCS · 2026Review
- UHPLC -Q-Orbitrap HRMS Integrated with Network Pharmacology Reveals the Anti-COPD Mechanism of Jianzhong Peiyuan Decoction and Functional Validation of Core Component Luteolin.Journal of inflammation research · 2026Article
- Advances in the mechanisms of electroacupuncture in the treatment of cerebral ischemia-reperfusion injury.Frontiers in neuroscience · 2026Review
- Mechanism-Driven Translation of Electroacupuncture for Depression: Bridging the Gap Between Preclinical and Clinical Research.Neuropsychiatric disease and treatment · 2026Review
- Depression and Gastrointestinal Health Abnormalities: Treatment Approaches from the Perspective of Traditional Chinese Medicine.Neuropsychiatric disease and treatment · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aims to investigate the efficacy of electroacupuncture in treating inflammatory bowel disease (IBD) accompanied by depressive symptoms. The potential mechanisms of electroacupuncture are also investigated, particularly in terms of its modulation of oxidative stress and NLRP3 inflammasomes to influence microglial activation and neuroinflammation, thereby alleviating depressive symptoms. Material and methods: The inflammatory bowel disease model in mice was induced by dextran sulfate sodium (DSS), and the mice were randomly assigned to the CON group, DSS group, DSS+EA group, and DSS+ MCC950 group. The assessment of depressive-like behavior in mice involved behavioral tests, while the detection of oxidative stress in the PFC, NLRP3 inflammasomes, central inflammation expression, and microglial activation were conducted using enzyme-linked immunosorbent assay (ELISA), Western blot, immunofluorescence, and biochemical kits. Results: Mice in the DSS group exhibited significant depressive-like behavior, which was effectively alleviated by electroacupuncture intervention. The intervention also reduced the expression of inflammatory factors and microglial activation in the medial prefrontal cortex (PFC) region. Electroacupuncture effectively attenuated oxidative stress, suppressed the recruitment of NLRP3 inflammasomes, and mitigated central nervous system inflammation, with effects similar to those of the NLRP3 inhibitor MCC950. Conclusion: Electroacupuncture significantly alleviated depressive symptoms in IBD mice by inhibiting oxidative stress and microglial activation in the PFC region, thereby ameliorating the neuroinflammatory environment. The findings can provide new theoretical and scientific support for the clinical application of electroacupuncture in treating depressive symptoms associated with IBD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.