Evidence map›Paper›PMID 40908723›Full record

ArticleHead & neck2026

Three-Dimensional Presentation of Tongue Squamous Cell Carcinoma Histopathology and Magnetic Resonance Imaging-A Novel Image Fusion Method.

Anne Koivuholma, Heli J Sistonen, Katri Aro, Alexandria L Irace, Antti Mäkitie, Jaana Hagström, Timo Atula

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anne KoivuholmaDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-2590-2225
Heli J SistonenDepartment of Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0003-0224-9750
Katri AroDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0001-8103-5237
Alexandria L IraceDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4758-3146
Antti MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-0451-2404
Jaana HagströmDepartment of Pathology, HUSLAB, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID 0000-0001-6079-7881
Timo AtulaDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-6560-1128

Funding

Finnish Association of Otorhinolaryngology-Head and Neck SurgeryFinnish Cultural FoundationIda Montin FoundationIda Montinin SäätiöKorvatautien TutkimussäätiöSuomen Kulttuurirahasto
6 · The paper itself

Abstract

backgroundThree-dimensional (3D) modeling has been used in the management of bony head and neck tumors, but not in soft tissue tumors. Currently, histopathological findings of oral squamous cell carcinomas (OSCC) are presented as two-dimensional images. Previously, we developed a 3D image fusion method that presents tumor histopathology and MRI in 3D form. In this study, we sought to test our method in a series of OSCCs.

methodsA 3D table scanner, 3D Slicer software, and 3D modeling software were used to produce 3D image fusions of nine OSCCs.

resultsNine OSCCs are presented as digital, 3D image fusions, showing the resected specimen and the tumor within based on histopathology and MRI.

conclusionsThe fused 3D model allows for a better visual understanding of tumor orientation within the resected specimen, provides a tool to compare tumor volume and dimensions between MRI images and histopathology slides, and facilitates multidisciplinary discussion.

Indexed as

Carcinoma, Squamous CellImaging, Three-DimensionalMagnetic Resonance ImagingTongue NeoplasmsAgedFemaleHumansMaleMiddle Agedcancercomputer aided designhistopathologymagnetic resonance imagingoral squamous cell carcinomathree‐dimensional reconstructiontongue

Identifiers

PMID40908723
PMCPMC12797015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.