Evidence map›Paper›PMID 40908721›Full record

ReviewExpert review of anticancer therapy2025

Importance of radiation-related cognitive decline in older adults who receive cranial radiation.

Felicia H Lew, Karl Cristie Figuracion, Shannon E Fogh, David P Sheppard, Yolanda D Tseng, Lia M Halasz, Jerome J Graber, Samuel Emerson, Simon S Lo, Sara J Hardy

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert review of anticancer therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Felicia H LewDepartment of Radiation Oncology, University of Washington, Seattle, WA, USA.
Karl Cristie FiguracionDepartment of Radiation Oncology, University of Washington, Seattle, WA, USA.
Shannon E FoghDepartment of Radiation Oncology, University of Washington, Seattle, WA, USA.
David P SheppardDepartment of Radiation Oncology, University of Washington, Seattle, WA, USA.
Yolanda D TsengDepartment of Radiation Oncology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4070-346X
Lia M HalaszDepartment of Radiation Oncology, University of Washington, Seattle, WA, USA.
Jerome J GraberAlvord Brain Tumor Center, University of Washington, Seattle, WA, USA.
Samuel EmersonAlvord Brain Tumor Center, University of Washington, Seattle, WA, USA.
Simon S LoDepartment of Radiation Oncology, University of Washington, Seattle, WA, USA.
Sara J HardyDepartment of Radiation Oncology, University of Washington, Seattle, WA, USA.

Funding

Biobehavioral Cancer Prevention and Control Training Program (BCPT)T32CA092408 · NCI · UNIVERSITY OF WASHINGTON · PI Margaret A Hannon · 2016 to 2026
$2.3M
Enriching Neuro-Oncology Survivorship: A Novel Symptom Management Education to Living Fully (SELF)K99CA303787 · NCI · FRED HUTCHINSON CANCER CENTER · PI Karl Cristie F Figuracion · 2025 to 2026
$211k
NCI NIH HHS K99 CA303787NCI NIH HHS L30 CA305599NCI NIH HHS T32 CA092408
6 · The paper itself

Abstract

introductionRadiation-related cognitive decline (RRCD), characterized by a decline in cognitive functioning within domains, such as memory and executive function, is a known potential consequence of cranial radiation. Older adults are disproportionately vulnerable to cognitive side effects of radiation (RT), and there can be significant impacts on quality of life and independence. Various mechanisms underlying the development of RRCD have been proposed but have not been specifically evaluated in older adults. AREAS COVERED: In this article, we review the studies that have evaluated cognitive effects of cranial radiation in older adults and discuss the mechanisms and factors that may lead to increased vulnerability of RRCD development in older adults. EXPERT OPINION: The review of the literature is limited by the variety of cognitive outcome measurements used as well as different ages evaluated. However, most studies support increased vulnerability to RRCD in older adults. No studies include geriatric assessment or other measures of biological age. Potential interventions include redefining whether different dose constraints are warranted in the older adult population, evaluating new medication interventions and utilizing radiation techniques that treat smaller volumes. Further research is needed to determine whether there is a corresponding reduction in RRCD.

Indexed as

Cognitive DysfunctionCranial IrradiationRadiation InjuriesAgedAge FactorsCognitionExecutive FunctionGeriatric AssessmentHumansQuality of Lifebrain metastasesbrain tumorscognitioncranial radiationgeriatric oncologyolder adultsRadiation related cognitive declinewhole brain radiation

Identifiers

PMID40908721
PMCPMC13142257

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.