Evidence map›Paper›PMID 40908711›Full record

Trial reportThe Journal of manual & manipulative therapy2026

Manual therapy reduces pain, disability and oxidative stress in patients with chronic non-specific neck pain; a double-blind, randomized pilot study.

Betsos Theodoros, Zemadanis Konstantinos, Papadea Polyxeni, Skipitari Marianna, Kalaitzopoulou Electra, Varemmenou Athina, Michail Effimia, Philippou Anastasios, Georgiou Christos D

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of manual & manipulative therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Betsos TheodorosPhysiology Laboratory, Faculty of Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0003-1690-7400
Zemadanis KonstantinosPhysiology Laboratory, Faculty of Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Papadea PolyxeniDepartment of Biology, University of Patras, Patras, Greece.
Skipitari MariannaDepartment of Biology, University of Patras, Patras, Greece.
Kalaitzopoulou ElectraDepartment of Biology, University of Patras, Patras, Greece.
Varemmenou AthinaDepartment of Medicine, University of Patras, Patras, Greece.
Michail EffimiaDepartment of Biology, University of Patras, Patras, Greece.
Philippou AnastasiosPhysiology Laboratory, Faculty of Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Georgiou Christos DDepartment of Biology, University of Patras, Patras, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesChronic nonspecific neck pain (CNNP) affects millions of people; nonetheless, several mechanistic details remain unknown. Oxidative stress (OS) is believed to be a contributing factor; however, its connection with manual therapy (MT), the current CNNP treatment, remains poorly investigated. Herein, the effects of low-velocity low-amplitude (LVLA) and high-velocity high-amplitude (HVLA) MT on pain relief, disability, and OS levels of CNNP patients are investigated.

methodsThe study follows a double-blind randomized pilot study design. OS is assessed using blood serum lipid hydroperoxides (LOOH). MT is assessed by using the Numeric Pain Rating Scale (NPRS) and the Neck Disability Index (NDI). Finally, the results are compared with those of patients receiving a sham intervention.

resultsMixed ANOVA revealed that MT affects blood serum LOOH levels in CNNP patients. Pre-intervention, mean LOOH levels of CNNP patients ( DISCUSSION/

conclusionThe results indicate that HVLA-LVLA MT causes significant decreases in pain and OS levels and improves function. Therefore, OS assessment in patients with CNNP could assist the evaluation of MT effectiveness in pain relief.

Indexed as

Chronic PainMusculoskeletal ManipulationsNeck PainOxidative StressAdultDisability EvaluationDouble-Blind MethodFemaleHumansLipid PeroxidesMaleMiddle AgedPain MeasurementPilot ProjectsLipid PeroxidesChiropracticlipid hydroperoxidesManipulationmanual therapyOxidative stress

Identifiers

PMID40908711
PMCPMC13182143

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.