Evidence map›Paper›PMID 40908692›Full record

ReviewMini reviews in medicinal chemistry2026

The Use of Artificial Intelligence in the Formulation of Effervescent Tablets: A Review.

Kalathum Padikkal Arunraj, Koradath Meethal Haritha, Machilakath Thandamparmbil Khulood, Palasserri Ayisha Sana, Kuriyedath Parambil Khadeeja Thanha, Kannissery Pramod

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mini reviews in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kalathum Padikkal ArunrajCollege of Pharmaceutical Sciences, Government Medical College, Kozhikode, 673008, Kerala, India.
Koradath Meethal HarithaCollege of Pharmaceutical Sciences, Government Medical College, Kozhikode, 673008, Kerala, India.
Machilakath Thandamparmbil KhuloodCollege of Pharmaceutical Sciences, Government Medical College, Kozhikode, 673008, Kerala, India.
Palasserri Ayisha SanaCollege of Pharmaceutical Sciences, Government Medical College, Kozhikode, 673008, Kerala, India.
Kuriyedath Parambil Khadeeja ThanhaCollege of Pharmaceutical Sciences, Government Medical College, Kozhikode, 673008, Kerala, India.
Kannissery PramodCollege of Pharmaceutical Sciences, Government Medical College, Kozhikode, 673008, Kerala, India.ORCID 0000-0002-8689-3369

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial Intelligence (AI) is emerging as a valuable tool in pharmaceutical formulations, including the development of effervescent tablets (ETs). This review highlights how AI techniques are being explored to support ET formulation designs, optimize component ratios, predict disintegration and dissolution behavior, and control reactions through artificial neural networks, support vector machines, and machine learning. These techniques have been applied in recent studies to enhance stability, improve disintegration times, and flavor masking. Computational fluid dynamics simulations of effervescence and dissolution are underexplored for ETs. Data-driven approaches, like response surface modeling, require ingredient concentrations, tablet properties, consumer preferences, and predictive analytics for optimization. However, limited comprehensive datasets, complex reactions, environmental sensitivities, and ethical/regulatory considerations pose challenges. Overcoming these obstacles, as identified in the current literature, could enable AI to innovate ET development and personalization.

Indexed as

Artificial IntelligenceDrug CompoundingTabletsChemistry, PharmaceuticalHumansNeural Networks, ComputerSoft ComputingTabletsArtificial intelligenceartificial neural networkcomputer-assisted drug designeffervescent tabletsformulationimprove flavor maskingmachine learning

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.